Introduction：Basic information about CAS 92761-26-7|ecamsule, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ecamsule |
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| CAS Number | 92761-26-7 | Molecular Weight | 562.695 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C28H34O8S2 | Melting Point | 255° (dec) |
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| MSDS | ChineseUSA | Flash Point | / |
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| Symbol |
GHS05 | Signal Word | Danger |
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Names
| Name | Ecamsule |
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| Synonym | More Synonyms |
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ecamsule BiologicalActivity
| Description | Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) [1] [2]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| In Vitro | Ecamsule is a broad-spectrum UVA-absorber with maximum absorbance at 344 nm[1]. Wild-type Fibs E6/E7 cells are more sensitive towards Ecamsule (200-1600 μM) treatment[1]. . Ecamsule counteractes UV and AAPH induced ROS-formation[1]. .The effects are dose-dependent, reaching a maxi-mum ROS reduction by 25.7% at the highest tested concentration of 1600 μM in the UV-setting. With the same concentration of Ecamsule, oxidative stress that had been trigged by AAPH is reduced by 10.8% and basal levels are attenuated by 16.9%[1]. . Ecamsule increases the viability at the highest applied concentration of 1600 μM in the AAPH-treated cells[1]. |
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| References | [1]. Stefanie Hofer, et al. Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells. ALTEX. 2019;36(2):231-244. [2]. DeLeo VA, et al. A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions. Cutis. 2009 Feb;83(2):95-103. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Melting Point | 255° (dec) |
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| Molecular Formula | C28H34O8S2 |
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| Molecular Weight | 562.695 |
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| Exact Mass | 562.169495 |
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| PSA | 159.64000 |
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| LogP | 1.35 |
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| Index of Refraction | 1.631 |
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| InChIKey | HEAHZSUCFKFERC-UHFFFAOYSA-N |
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| SMILES | CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2=Cc1ccc(C=C2C(=O)C3(CS(=O)(=O)O)CCC2C3(C)C)cc1 |
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Safety Information
| Symbol |
GHS05 |
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| Signal Word | Danger |
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| Hazard Statements | H318 |
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| Precautionary Statements | P280-P305 + P351 + P338 + P310 |
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| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | 41 |
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| Safety Phrases | 26-39 |
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| RIDADR | NONH for all modes of transport |
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Synonyms
| 3,3'-(1,4-Phenylenedimethylidyne)bis[7,7-dimethyl-2-oxo-bicyclo[2.2.1]heptane-1-methanesulfonic Acid] |
| Mexoryl SX |
| 3,3'-(1,4-Phenylenedimethylidyne)bis(7,7-dimethyl-2-oxobicyclo(2.2.1)heptane-1-methanesulfonic acid) |
| Terephthalylidene-3,3'-dicamphor-10,10'-disulfonic Acid |
| (1,4-Phenylene bis{(Z)methylylidene[(3Z)-7,7-dimethyl-2-oxobicyclo [2.2.1]hept-1-yl-3-ylidene]})dimethanesulfonic acid |
| (1,4-Phenylenebis{(Z)methylylidene[(3Z)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl-3-ylidene]})dimethanesulfonic acid |
| Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 3,3'-[1,4-phenylenedi(Z)methylidyne]bis[7,7-dimethyl-2-oxo-, (3Z)- |
