Introduction：Basic information about CAS 58142-99-7|DSRM-3716, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | DSRM-3716 |
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| CAS Number | 58142-99-7 | Molecular Weight | 255.06 |
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| Density | 1.8±0.1 g/cm3 | Boiling Point | 336.8±15.0 °C at 760 mmHg |
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| Molecular Formula | C9H6IN | Melting Point | / |
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| MSDS | / | Flash Point | 157.5±20.4 °C |
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Names
| Name | 5-Iodoisoquinoline |
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| Synonym | More Synonyms |
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DSRM-3716 BiologicalActivity
| Description | DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. DSRM-3716 is selective against other NAD+-processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| Target | IC50: 75 nM (SARM1 NADase)[1] |
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| In Vitro | DSRM-3716 treatment produces dose-dependent inhibition of cADPR increase (IC50 of 2.8 μM) and substantial preservation of NAD+ in these cultures in a manner consistent with engagement and inhibition of SARM1 enzymatic NADase activity inside the cells[1]. DSRM-3716 prevents neurofilament light chain (NfL) release from severed axons in a dose-dependent manner, with an IC50 of ~2 μM[1]. The potency of DSRM-3716 to inhibit cADPR increase caused by axotomy (IC50 of 2.8 μM) is similar to the potency required to prevent axonal degeneration (IC50 of 2.1 μM)[1]. DSRM-3716 inhibits the SARM1-dependent cell destruction pathway triggered by Rotenone in sensory neurons[1]. |
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| References | [1]. Robert O Hughes, et al. Small Molecule SARM1 Inhibitors Recapitulate the SARM1 -/- Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate. Cell Rep. 2021 Jan 5;34(1):108588. |
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Chemical & Physical Properties
| Density | 1.8±0.1 g/cm3 |
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| Boiling Point | 336.8±15.0 °C at 760 mmHg |
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| Molecular Formula | C9H6IN |
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| Molecular Weight | 255.06 |
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| Flash Point | 157.5±20.4 °C |
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| Exact Mass | 254.954483 |
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| PSA | 12.89000 |
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| LogP | 2.99 |
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| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
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| Index of Refraction | 1.724 |
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| InChIKey | CUILFTFMBBGSFT-UHFFFAOYSA-N |
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| SMILES | Ic1cccc2cnccc12 |
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| Storage condition | 2-8°C |
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Safety Information
Synonyms
| 5-Iodoisoquinoline |
| Isoquinoline, 5-iodo- |
| Isoquinoline,5-iodo |
| 5-iodo-isoquinoline |
| 5-Jod-isochinolin |
