CAS 64520-05-4|amitriptyline metabolite (+/-)-
Introduction：Basic information about CAS 64520-05-4|amitriptyline metabolite (+/-)-, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | amitriptyline metabolite (+/-)- | ||
|---|---|---|---|
| CAS Number | 64520-05-4 | Molecular Weight | 293.40300 |
| Density | 1.151g/cm3 | Boiling Point | 453.3ºC at 760mmHg |
| Molecular Formula | C20H23NO | Melting Point | 97-99 °C |
| MSDS | USA | Flash Point | 225.4ºC |
Names
| Name | (11E)-11-[3-(dimethylamino)propylidene]-5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-5-ol |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Density | 1.151g/cm3 |
|---|---|
| Boiling Point | 453.3ºC at 760mmHg |
| Melting Point | 97-99 °C |
| Molecular Formula | C20H23NO |
| Molecular Weight | 293.40300 |
| Flash Point | 225.4ºC |
| Exact Mass | 293.17800 |
| PSA | 23.47000 |
| LogP | 3.65950 |
| Appearance of Characters | solid | white |
| Index of Refraction | 1.651 |
| InChIKey | GHWBJXOKAFHZAI-SFQUDFHCSA-N |
| SMILES | CN(C)CCC=C1c2ccccc2CC(O)c2ccccc21 |
| Water Solubility | 0.1 M HCl: soluble |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles15
More Articles| Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes. Clin. Pharmacol. Ther. 52(4) , 350-8, (1992) In 26 hospitalized patients with depression, a combined pharmacogenetic test with dextromethorphan, a substrate of cytochrome P450IID6, and mephenytoin, the S-form of which is hydroxylated by a P450II... | |
| Demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline in human liver microsomes. Drug Metab. Dispos. 9(6) , 565-8, (1981) The rates of demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline by microsomes from adult human livers were determined by use of mass-fragmentographic or liqui... | |
| CYP2D6 and CYP2C19 genotypes and amitriptyline metabolite ratios in a series of medicolegal autopsies. Forensic Sci. Int. 158(2-3) , 177-83, (2006) In a series of 202 postmortem toxicology cases, the CYP2D6 and CYP2C19 genes were genotyped, and the concentrations of amitriptyline (AT) and six metabolites were analyzed. The polymorphic CYP2D6 and ... |
Synonyms
| 5H-Dibenzo(a,d)cyclohepten-10-ol,5-(3-(dimethylamino)propylidene)-10,11-dihydro-,(E) |
| ( inverted exclamation markA)-(E)-5-[3-(Dimethylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol |
| Amitriptyline metabolite,( inverted exclamation markA)-E-10-hydroxylated |
