Introduction：Basic information about CAS 3368-13-6|Benzolamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Benzolamide |
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| CAS Number | 3368-13-6 | Molecular Weight | 320.36900 |
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| Density | 1.746g/cm3 | Boiling Point | 585.9ºC at 760mmHg |
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| Molecular Formula | C8H8N4O4S3 | Melting Point | / |
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| MSDS | / | Flash Point | 308.2ºC |
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Names
| Name | 5-(benzenesulfonamido)-1,3,4-thiadiazole-2-sulfonamide |
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| Synonym | More Synonyms |
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Benzolamide BiologicalActivity
| Description | Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures[1][2][3]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Carbonic AnhydraseResearch Areas >>Neurological Disease |
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| Target | Ki: 15 nM (hCA I), 9 nM (hCA II), 94 nM (EcoCAγ), 78 nM (VchCAγ), 54 nM (CAS3)[1][2] |
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| In Vitro | Benzolamide inhibits hCA I, hCA II, EcoCAγ and VchCAγ, with Kis of 15 nM, 9 nM, 94 nM and 78 nM, respectively[1]. Benzolamide shows selectivity for CAS3 (Ki=54 nM) over CAS1 (Ki=2115 nM) and CAS2 (Ki=410 nM)[2]. |
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| In Vivo | Benzolamide (90 µmol/kg; i.p.) decreases brain pH and suppresses electrographic post-asphyxia seizures in rats[3]. Animal Model: Male and female Wistar Han rats (11-day-old)[3] Dosage: 90 µmol/kg Administration: A single i.p. Result: Induced a fast brain acidosis of a comparable magnitude. Suppressed electrographic seizures after asphyxia by slowing down the recovery of brain pH. |
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| References | [1]. Prete SD, et, al. Escherichia coli γ-carbonic anhydrase: characterisation and effects of simple aromatic/heterocyclic sulphonamide inhibitors. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1545-1554. [2]. Vullo D, et, al. Sulfonamide Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous Ascomycete Sordaria macrospora. Molecules. 2020 Feb 25;25(5):1036. [3]. Pospelov AS, et, al. Carbonic anhydrase inhibitors suppress seizures in a rat model of birth asphyxia. Epilepsia. 2021 Jun 27. |
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Chemical & Physical Properties
| Density | 1.746g/cm3 |
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| Boiling Point | 585.9ºC at 760mmHg |
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| Molecular Formula | C8H8N4O4S3 |
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| Molecular Weight | 320.36900 |
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| Flash Point | 308.2ºC |
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| Exact Mass | 319.97100 |
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| PSA | 177.11000 |
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| LogP | 2.92120 |
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| Index of Refraction | 1.689 |
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| InChIKey | PWDGTQXZLNDOKS-UHFFFAOYSA-N |
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| SMILES | NS(=O)(=O)c1nnc(NS(=O)(=O)c2ccccc2)s1 |
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| Storage condition | 2-8°C |
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Safety Information
Customs
| HS Code | 2935009090 |
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| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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Synonyms
| 3dbu |
| benzenesulfonylamino-[1,3,4]thiadiazole-2-sulfonic acid amide |
| 5-phenylsulfonamide-1,3,4-thiadiazole-2-sulfonamide |
| 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide |
| W 1803 |
| 2-(Phenylsulfonylamino)-1,3,4-thiadiazole-5-sulfonamide |
| 5-benzenesulfonamido-1,3,4-thiadiazol-2-sulfonamide |
| 1,3,4-Thiadiazole-2-sulfonamide,5-((phenylsulfonyl)amino) |
| D8W |
| 2-benzenesulfonamido-1,3,4-thiadiazole-5-sulfonamide |
| Benzolamide (BZA) |
| BENZOLAMIDE |
