Introduction：Basic information about CAS 292633-16-0|Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt |
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| CAS Number | 292633-16-0 | Molecular Weight | 711.719 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 1258.1±65.0 °C at 760 mmHg |
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| Molecular Formula | C33H41N7O11 | Melting Point | / |
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| MSDS | / | Flash Point | 714.6±34.3 °C |
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Names
| Name | ac-leu-glu-his-asp-amc |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Ac-LEHD-AMC is a fluorogenic substrate for caspase-9 (Excitation: 341 nm; Emission: 441 nm). Caspase-9 can induce hydrolysis of Ac-LEHD-AMC, resulting in the release of AMC fluorophore and its fluorescence can be used to quantify caspase-9 activity[1]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Apoptosis >>Caspase |
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| References | [1]. Igor M Prudnikov, et al. Short peptide tools for monitoring caspase and proteasome activities in embryonal and adult rat brain lysates: an approach for the differential identification of proteases. J Biochem. 2012 Mar;151(3):299-316. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 1258.1±65.0 °C at 760 mmHg |
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| Molecular Formula | C33H41N7O11 |
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| Molecular Weight | 711.719 |
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| Flash Point | 714.6±34.3 °C |
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| Exact Mass | 711.286377 |
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| PSA | 278.99000 |
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| LogP | 0.94 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.605 |
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| InChIKey | UOZNIAKIZDCQSH-NATPOTRJSA-N |
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| SMILES | CC(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(CC(=O)O)C(=O)Nc1ccc2c(C)cc(=O)oc2c1.O=C(O)C(F)(F)F |
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Synonyms
| N-Acetyl-L-leucyl-L-α-glutamyl-L-histidyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-α-asparagine |
| ac-lehd-amc trifluoroacetate salt |
| L-α-Asparagine, N-acetyl-L-leucyl-L-α-glutamyl-L-histidyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- |
| ac-lehd-amc |
| ac-lehd-mca |
| n-acetyl-leu-glu-his-asp-7-amino-4-methylcoumarin amc |
| ac-leu-glu-his-asp-mca |
| ac-leu-glu-his-asp-7-amino-4-methylcoumarin |
