Introduction：Basic information about CAS 331741-94-7|Pargluva, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pargluva |
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| CAS Number | 331741-94-7 | Molecular Weight | 516.54200 |
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| Density | 1.274g/cm3 | Boiling Point | 736.4ºC at 760 mmHg |
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| Molecular Formula | C29H28N2O7 | Melting Point | / |
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| MSDS | / | Flash Point | 399.2ºC |
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Names
| Name | Muraglitazar |
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| Synonym | More Synonyms |
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Pargluva BiologicalActivity
| Description | Muraglitazar is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARα (EC50 = 320 nM) and PPARγ(EC50 = 110 nM)[1]. |
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| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>PPARResearch Areas >>Metabolic Disease |
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| References | [1]. Buse JB, Rubin CJ, Frederich R, et al. Muraglitazar, a dual (alpha/gamma) PPAR activator: a randomized, double-blind, placebo-controlled, 24-week monotherapy trial in adult patients with type 2 diabetes. Clin Ther. 2005;27(8):1181-1195. [2]. Cox SL. Muraglitazar: an agent for the treatment of type 2 diabetes and associated dyslipidemia. Drugs Today (Barc). 2005;41(9):579-587. |
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Chemical & Physical Properties
| Density | 1.274g/cm3 |
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| Boiling Point | 736.4ºC at 760 mmHg |
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| Molecular Formula | C29H28N2O7 |
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| Molecular Weight | 516.54200 |
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| Flash Point | 399.2ºC |
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| Exact Mass | 516.19000 |
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| PSA | 120.12000 |
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| LogP | 4.81940 |
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| Index of Refraction | 1.601 |
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| InChIKey | IRLWJILLXJGJTD-UHFFFAOYSA-N |
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| SMILES | COc1ccc(OC(=O)N(CC(=O)O)Cc2ccc(OCCc3nc(-c4ccccc4)oc3C)cc2)cc1 |
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Synonyms
| 2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid |
