Introduction：Basic information about CAS 477-49-6|Podophyllotoxinone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Podophyllotoxinone |
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| CAS Number | 477-49-6 | Molecular Weight | 412.38900 |
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| Density | 1.365 g/cm3 | Boiling Point | 602.3±55.0℃ at 760 mmHg |
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| Molecular Formula | C22H20O8 | Melting Point | 191.73℃ |
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| MSDS | / | Flash Point | / |
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Names
| Name | (-)-podophyllotoxon |
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| Synonym | More Synonyms |
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Podophyllotoxinone BiologicalActivity
| Description | Podophyllotoxone is isolated from the roots of Dysosma versipellis and has anti-cancer activities.Podophyllotoxone is able to inhibit the tubulin polymerization[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Microtubule/TubulinSignaling Pathways >>Cytoskeleton >>Microtubule/Tubulin |
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| Target | Microtubule/Tubulin[1] |
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| In Vitro | Podophyllotoxone inhibits human prostate cancer cells PC3 and DU145 growth with IC50 values of 14.7 and 20.6 µM[1]. |
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| References | [1]. Juan Li , et al. Absolute Configuration of Podophyllotoxone and Its Inhibitory Activity Against Human Prostate Cancer Cells. Chin J Nat Med. 2015 Jan;13(1):59-64. |
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Chemical & Physical Properties
| Density | 1.365 g/cm3 |
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| Boiling Point | 602.3±55.0℃ at 760 mmHg |
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| Melting Point | 191.73℃ |
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| Molecular Formula | C22H20O8 |
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| Molecular Weight | 412.38900 |
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| Exact Mass | 412.11600 |
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| PSA | 89.52000 |
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| LogP | 2.55850 |
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| Vapour Pressure | 1.83E-14mmHg at 25°C |
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| InChIKey | ISCQYPPCSYRZOT-BKTGTZMESA-N |
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| SMILES | COc1cc(C2c3cc4c(cc3C(=O)C3COC(=O)C32)OCO4)cc(OC)c1OC |
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Synonyms
