CAS 3388-04-3|2-(3,4 epoxycyclohexyl)ethyltrimethoxysilane

CHEMICAL IDENTIFICATION

RTECS NUMBER :

VV4000000

CHEMICAL NAME :

Silane, beta-(3,4-epoxycyclohexyl)ethyltrimethoxy-

CAS REGISTRY NUMBER :

3388-04-3

LAST UPDATED :

199712

DATA ITEMS CITED :

10

MOLECULAR FORMULA :

C11-H22-O4-Si

MOLECULAR WEIGHT :

246.42

WISWESSER LINE NOTATION :

T36 BOTJ E2-SI-O1&O1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Open irritation test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/17/1972 ** ACUTE TOXICITY DATA **

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

8 mL/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JBMRBG Journal of Biomedical Materials Research. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1967- Volume(issue)/page/year: 8,11,1974

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1 mL/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JBMRBG Journal of Biomedical Materials Research. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1967- Volume(issue)/page/year: 8,11,1974

TYPE OF TEST :

LC - Lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>290 mg/m3/4H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JBMRBG Journal of Biomedical Materials Research. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1967- Volume(issue)/page/year: 8,11,1974

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

6300 uL/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 2/11/1964 ** TUMORIGENIC DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1587 gm/kg/76W-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors

REFERENCE :

FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 12,579,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9076 No. of Facilities: 367 (estimated) No. of Industries: 17 No. of Occupations: 23 No. of Employees: 15389 (estimated) No. of Female Employees: 3865 (estimated)

Se Pu 19(6) , 485-8, (2001)

A new silane coupling agent, beta-(3,4-epoxycyclohexyl)ethyltrimethoxy silane, was for the firsty time used to react with octanol, then the intermediate product was coupled onto porous silica to obtai...

Fundam. Appl. Toxicol. 10(3) , 439-52, (1988)

beta-(3,4-epoxycyclohexyl)ethyltrimethoxysilane (ECEMS, CAS No. 3388-04-3) is mutagenic in vitro and weakly carcinogenic in mice after dermal application. Timed pregnant Fischer 344 rats and New Zeala...

J. Photochem. Photobiol. A: Chem. 158(2) , 163-170, (2003)