CAS 6232-19-5|3-cyano-L-alanine
| Common Name | 3-cyano-L-alanine | ||
|---|---|---|---|
| CAS Number | 6232-19-5 | Molecular Weight | 114.103 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 368.1±32.0 °C at 760 mmHg |
| Molecular Formula | C4H6N2O2 | Melting Point | / |
| MSDS | USA | Flash Point | 176.4±25.1 °C |
Names
| Name | 3-cyano-L-alanine |
|---|---|
| Synonym | More Synonyms |
3-cyano-L-alanine BiologicalActivity
| Description | β-cyano-L-Alanine (Beta-cyano-l-alanine), a nitrile of widespread occurrence in higher plants, is enzymatically produced by cyanoalanine synthase from cyanide and cysteine as substrates[1]. β-cyano-L-Alanine abolishes the protective effect of ethanol on cerebral ischemia/reperfusion (I/R) injury[2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
| In Vivo | β-cyano-L-Alanine (intraperitoneally; 50 mg/kg) abolishes the protective effect of ethanol on cerebral ischemia/reperfusion (I/R) injury. Animal Model: Adult (postnatal age: 60 days) male C57BL/6J mice (25-30 g) gavage-fed with ethanol[2] Dosage: 50 mg/kg Administration: Intraperitoneally Result: Abolished the protective effect of ethanol on cerebral I/R injury. |
| References | [1]. Piotrowski M, et al. The Arabidopsis thaliana isogene NIT4 and its orthologs in tobacco encode beta-cyano-L-alanine hydratase/nitrilase.J Med Chem. J Biol Chem. 2001 Jan 26;276(4):2616-21. [2]. McCarter KD, et al. Influence of low-dose alcohol consumption on post-ischemic inflammation: Role of cystathionine γ-lyase. Alcohol. 2019 May;76:81-89. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 368.1±32.0 °C at 760 mmHg |
| Molecular Formula | C4H6N2O2 |
| Molecular Weight | 114.103 |
| Flash Point | 176.4±25.1 °C |
| Exact Mass | 114.042931 |
| PSA | 87.11000 |
| LogP | -0.72 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.502 |
| InChIKey | BXRLWGXPSRYJDZ-VKHMYHEASA-N |
| SMILES | N#CCC(N)C(=O)O |
| Storage condition | -20°C |
Safety Information
| RIDADR | NONH for all modes of transport |
|---|---|
| HS Code | 2926909090 |
Customs
| HS Code | 2926909090 |
|---|---|
| Summary | HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
Articles25
More Articles| Evolution of heteromeric nitrilase complexes in Poaceae with new functions in nitrile metabolism. Proc. Natl. Acad. Sci. U. S. A. 104(47) , 18848-53, (2007) Members of the nitrilase 4 (NIT4) family of higher plants catalyze the conversion of beta-cyanoalanine to aspartic acid and asparagine, a key step in cyanide detoxification. Grasses (Poaceae) possess ... | |
| Vicianin, prunasin, and beta-cyanoalanine in common vetch seed as sources of urinary thiocyanate in the rat. J. Agric. Food Chem. 49(10) , 5075-80, (2001) When young rats were fed a diet containing common vetch seed for 1 month, they excreted in the urine approximately 7 times more thiocyanate than they had ingested. Vicianin, prunasin, and beta-cyanoal... | |
| Maize nitrilases have a dual role in auxin homeostasis and beta-cyanoalanine hydrolysis. J. Exp. Bot. 58(15-16) , 4225-33, (2007) The auxin indole-3-acetic acid (IAA), which is essential for plant growth and development, is suggested to be synthesized via several redundant pathways. In maize (Zea mays), the nitrilase ZmNIT2 is e... |
Synonyms
| AmbotzHAA5740 |
| 3-cyano-L-alanine |
| b-Cyano-L-Alanine |
| Propanoic acid, 2-amino-3-cyano-, (2S)- |
| (2S)-2-Amino-3-cyanopropanoic acid |
| L-3-Cyanoalanine |
| β-Cyano-L-alanine |
| (S)-2-amino-3-cyanopropanoic acid |
| L-Alanine,3-cyano |
