Introduction：Basic information about CAS 82801-73-8|RKRARKE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | RKRARKE |
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| CAS Number | 82801-73-8 | Molecular Weight | 943.11 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C38H74N18O10 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | cGMP Dependent Kinase Inhibitor Peptide |
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| Synonym | More Synonyms |
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RKRARKE BiologicalActivity
| Description | PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 86 μM[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| Target | Ki: 86 μM (PKG)[1] |
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| In Vitro | Summary of experiments showing that intracellular dialysis of postsynaptic cells with PKG inhibitor PKG inhibitor peptide (1 mM) failed to alter the induction of long-term depression (CCh-LTD)[2]. |
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| References | [1]. Bhatnagar D, et al. Synthetic peptide analogues differentially alter the binding affinities of cyclic nucleotide dependent protein kinases for nucleotide substrates. Biochemistry. 1988 Mar 22;27(6):1988-94. [2]. Chiung-Chun Huang, et al. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex. 2010 Apr;20(4):982-96. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Molecular Formula | C38H74N18O10 |
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| Molecular Weight | 943.11 |
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| Exact Mass | 942.583557 |
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| PSA | 512.96000 |
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| LogP | -5.78 |
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| Index of Refraction | 1.658 |
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| InChIKey | OUKSKNTVYYVIMZ-DUJSLOSMSA-N |
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| SMILES | CC(NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)O |
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Synonyms
| L-Glutamic acid, N-(diaminomethylene)-L-ornithyl-L-lysyl-N-(diaminomethylene)-L-ornithyl-L-alanyl-N-(diaminomethylene)-L-ornithyl-L-lysyl- |
| Alg-Lys-Arg-Ala-Arg-Lys-Glu |
| cGMP-Dependent Protein Kinase Inhibitor Peptide |
| ARG-LYS-ARG-ALA-ARG-LYS-GLU |
| arginyl-lysyl-arginyl-alanyl-arginyl-lysyl-glutamic acid |
| RKRARKE |
| PKG INHIBITOR |
| PROTEIN KINASE G INHIBITOR |
| N-(Diaminomethylene)-L-ornithyl-L-lysyl-N-(diaminomethylene)-L-ornithyl-L-alanyl-N-(diaminomethylene)-L-ornithyl-L-lysyl-L-glutamic acid |
| H-ARG-LYS-ARG-ALA-ARG-LYS-GLU-OH |
