CAS 88107-10-2|LY 171883
Introduction：Basic information about CAS 88107-10-2|LY 171883, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | LY 171883 | ||
|---|---|---|---|
| CAS Number | 88107-10-2 | Molecular Weight | 318.37 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 553.0±60.0 °C at 760 mmHg |
| Molecular Formula | C16H22N4O3 | Melting Point | 117-119℃ |
| MSDS | ChineseUSA | Flash Point | 288.3±32.9 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | tomelukast |
|---|---|
| Synonym | More Synonyms |
LY 171883 BiologicalActivity
| Description | Tomelukast (LY171883) is an orally active leukotriene D4 and E4 antagonist. Tomelukast can be used for the research of asthma[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Leukotriene ReceptorResearch Areas >>Inflammation/Immunology |
| Target | leukotriene D4, leukotriene E4[1] |
| References | [1]. Abraham WM, et al. The effect of an orally active leukotriene D4/E4 antagonist, LY171883, on antigen-induced airway responses in allergic sheep. Prostaglandins. 1986 Mar;31(3):457-67. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 553.0±60.0 °C at 760 mmHg |
| Melting Point | 117-119℃ |
| Molecular Formula | C16H22N4O3 |
| Molecular Weight | 318.37 |
| Flash Point | 288.3±32.9 °C |
| Exact Mass | 318.169189 |
| PSA | 100.99000 |
| LogP | 3.27 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.574 |
| InChIKey | MWYHLEQJTQJHSS-UHFFFAOYSA-N |
| SMILES | CCCc1c(OCCCCc2nn[nH]n2)ccc(C(C)=O)c1O |
| Storage condition | Store at +4°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 650 mg/kg
- TOXIC EFFECTS :
- Liver - other changes
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18250 mg/kg/1Y-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Effect on specific coenzyme - NAD,NADP
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3010 mg/kg/2W-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Biochemical - Metabolism (Intermediary) - lipids including transport
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 63875 mg/kg/1Y-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
MUTATION DATA - TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 1260 mg/kg/1W (Continuous)
- REFERENCE :
- CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,1557,1991
- TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 1260 mg/kg/1W (Continuous)
- REFERENCE :
- CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,1557,1991
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | 36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | KM5780800 |
Articles26
More Articles| Role of leukotrienes in N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity in male Fischer 344 rats. Toxicology 300(1-2) , 92-9, (2012) The agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) can induce marked nephrotoxicity in rats following a single intraperitoneal (ip) administration of 0.4mmol/kg or greater. Although N... | |
| Effect of leukotriene C4 exposure on ciliated cells of the nasal mucosa. Prostaglandins 51(1) , 69-79, (1996) To clarify the effects of leukotriene C4 (LTC4) on human ciliated epithelium, ciliary activity of the ethmoid sinus mucosa was measured photoelectrically in tissue culture. At concentrations ranging f... | |
| Blood cell-vascular wall interactions and the production of coronary contracting sulfidopeptide leukotrienes in isolated, cell- perfused, rabbit heart. Adv. Prostaglandin. Thromboxane. Leukot. Res. 23 , 385-7, (1995) |
Synonyms
| MFCD00211057 |
| Ethanone, 1-[2-hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]- |
| Tomelukast |
| 1-[2-hydroxy-3-propyl-4-[4-(2H-tetrazol-5-yl)butoxy]phenyl]ethanone |
| 1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl}ethanone |
| Tomelukastum |
