CAS 63088-04-0|(±)-threo-3-Methylglutamic acid
Introduction：Basic information about CAS 63088-04-0|(±)-threo-3-Methylglutamic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (±)-threo-3-Methylglutamic acid | ||
|---|---|---|---|
| CAS Number | 63088-04-0 | Molecular Weight | 161.15600 |
| Density | 1.329g/cm3 | Boiling Point | 329.4ºC at 760 mmHg |
| Molecular Formula | C6H11NO4 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 153ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | (+/-)-threo-3-Methylglutamic Acid |
|---|---|
| Synonym | More Synonyms |
(±)-threo-3-Methylglutamic acid BiologicalActivity
| Description | (±)-threo-3-Methylglutamic acid is a potent EAAT2/4 inhibitor. (±)-threo-3-Methylglutamic acid also is an ionotropic glutamate receptor agonist. (±)-threo-3-Methylglutamic acid inhibits glutamate uptake by rod outer segments[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>EAAT2Research Areas >>Metabolic Disease |
| In Vitro | (±)-threo-3-Methylglutamic acid (0-300 µM) 以浓度依赖性方式抑制视杆外节对谷氨酸的摄取，IC50 值为 38.35 µM[2]。 |
| References | [1]. Eliasof S, et al. Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems. J Neurochem. 2001 Apr;77(2):550-7. [2]. Pignataro L, et al. Nonsynaptic localization of the excitatory amino acid transporter 4 in photoreceptors. Mol Cell Neurosci. 2005 Mar;28(3):440-51. |
Chemical & Physical Properties
| Density | 1.329g/cm3 |
|---|---|
| Boiling Point | 329.4ºC at 760 mmHg |
| Molecular Formula | C6H11NO4 |
| Molecular Weight | 161.15600 |
| Flash Point | 153ºC |
| Exact Mass | 161.06900 |
| PSA | 100.62000 |
| LogP | 0.20940 |
| Appearance of Characters | white to off-white |
| Index of Refraction | 1.512 |
| InChIKey | FHJNAFIJPFGZRI-WVZVXSGGSA-N |
| SMILES | CC(CC(=O)O)C(N)C(=O)O |
| Storage condition | Store at RT |
| Water Solubility | H2O: >1.5mg/dL |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2922499990 |
Customs
| HS Code | 2922499990 |
|---|---|
| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
Articles2
More Articles| Guide to Receptors and Channels (GRAC), 4th Edition. Br. J. Pharmacol. 158 Suppl 1 , S1-254, (2009) | |
| In vitro comparison of the effect of inhalation delay and flow rate on the emitted dose from three valved holding chambers. J. Aerosol Med. Pulm. Drug Deliv. 27 Suppl 1 , S37-43, (2014) Valved holding chambers (VHCs) are accessory devices for pressurized metered dose inhalers (pMDIs). Use of a VHC may help overcome coordination issues associated with drug delivery via the pMDI alone.... |
Synonyms
| (±)-threo-3-Methylglutamic acid |
