CAS 107761-42-2|β-Amyloid-42
Introduction：Basic information about CAS 107761-42-2|β-Amyloid-42, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | β-Amyloid-42 | ||
|---|---|---|---|
| CAS Number | 107761-42-2 | Molecular Weight | 4514.04000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C203H311N55O60S | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | Amyloid|A-Peptide (1-42) (human) |
|---|---|
| Synonym | More Synonyms |
β-Amyloid-42 BiologicalActivity
| Description | Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. |
|---|---|
| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Amyloid-βResearch Areas >>Neurological Disease |
| In Vitro | Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Application of Amyloid β-Peptide (1-42) human (1 to 10 μM) in the bathing solution does not change delayed rectifier K+-current and leakage current, but enhances inactivation of Са2+-current and blocks Са2+-dependent К+-current[1]. At 2.5 μM concentration, Amyloid β-Peptide (1-42) human reduces viability of SH-SY5Y cells to 65%. Results show that Amyloid β-Peptide (1-42) human localizes in both the cytoplasm and nucleus of SH-SY5Y cells after 30 min of incubation and after 8 h. In the latter, large accumulations of Amyloid β-Peptide (1-42) human are seen in the cytoplasm and in the nucleus. Increased APP mRNA levels are also detected upon Amyloid β-Peptide (1-42) human treatment[2]. |
| Cell Assay | SH-SY5Y cells are treated with biotinylated Amyloid β-Peptide (1-42) human peptide 1 μM. Cells are fixed and permeabilized with 3.3% formaldehyde containing 0.5% Triton X-100 followed by 125 mM glycine in PBS containing magnesium and calcium. Cells are blocked with 5% fetal bovine calf serum followed by the primary antibody. Biotin-Amyloid β-Peptide (1-42) human peptide is detected with the monoclonal antibody AB or alternatively with Avidin Fluor488. Nuclei are stained with DAPI. Images are obtained using an LSM 510 meta confocal microscope[2]. |
Chemical & Physical Properties
| Molecular Formula | C203H311N55O60S |
|---|---|
| Molecular Weight | 4514.04000 |
| Exact Mass | 4511.27000 |
| PSA | 1840.49000 |
| LogP | 1.35150 |
| Storage condition | −20°C |
Safety Information
| Safety Phrases | 24/25 |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 29332900 |
Articles6
More Articles| Genotype-driven isolation of enterocin with novel bioactivities from mangrove-derived Streptomyces qinglanensis 172205. Appl. Microbiol. Biotechnol. 99 , 5825-32, (2015) The type II polyketide synthase (PKS) natural product enterocin (1) was isolated from a mangrove-derived novel species Streptomyces qinglanensis 172205 guided by genome sequence, and its putative bios... | |
| The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry 32 , 4693-4697, (1993) Several variants of the beta amyloid protein, differing only at their carboxy terminus (beta 1-39, beta 1-40, beta 1-42, and beta 1-43), have been identified as the major components of the cerebral am... | |
| Induction of neuronal death by microglial AGE-albumin: implications for Alzheimer's disease. PLoS ONE 7 , e37917, (2012) Advanced glycation end products (AGEs) have long been considered as potent molecules promoting neuronal cell death and contributing to neurodegenerative disorders such as Alzheimer's disease (AD). In ... |
Synonyms
| β-amyloid 42 |
| Amyloid Beta-Peptide (1-42) (human) |
| beta-Amyloid (1-42) human |
| β-amyloid polypeptide 42 |
| β-amyloid protein 42 |
| MFCD01864012 |
| Human β-amyloid peptide (1-42) |
| DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA |
| Bate-Amyloid （ 1-42 ） human |
| Amyloid β-Peptide (1-42) (human) |
