CAS 69698-54-0|VIP (6-28) (human, mouse, rat) trifluoroacetate salt

Introduction：Basic information about CAS 69698-54-0|VIP (6-28) (human, mouse, rat) trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles5
6. Synonyms

Common Name	VIP (6-28) (human, mouse, rat) trifluoroacetate salt
CAS Number	69698-54-0	Molecular Weight	2816.28000
Density	/	Boiling Point	/
Molecular Formula	C₁₂₆H₂₀₇N₃₇O₃₄S	Melting Point	/
MSDS	ChineseUSA	Flash Point	/

Names

Name	6-28-Vasoactiveintestinal Octacosapeptide
Synonym	More Synonyms

BiologicalActivity

Description	VIP(6-28)(human, rat, porcine, bovine) is an effective antagonist of the actions of exogenous vasoactive intestinal peptide (VIP) on cAMP.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic DiseasePeptides
Target	VIP[1]
In Vitro	VIP(6-28) is an effective VIP antagonist in the superior cervical ganglion (SCG) , and results obtained using this analog indicate that endogenous VIP can participate in a positive feedback loop in injured sympathetic neurons in which it enhances its own expression. VIP(6-28), when added to short-term cultures of adult SCG at a concentration of 10, 30, or 100 μM, reduces the increase in cAMP levels produced by stimulation with 10 μM VIP by 52, 64, or 81%, respectively. At any of these concentrations tested, VIP(6-28) by itself does not alter cAMP levels. In contrast to its ability to reduce the VIP-stimulated elevation in cAMP levels by 64%, the addition of 30 μM VIP(6-28) to culture medium does not significantly alter cAMP levels measured after stimulation of adult ganglia with either isoproterenol or forskolin (10 μM each). Similar results on the ability of VIP(6-28) to block VIP-stimulated increases in cAMP levels are obtained in neuron-enriched and in non-neuronal cell-enriched dissociated cultures[1].
Kinase Assay	Adult rats are killed by decapitation. The SCGs are removed, desheathed, placed in organ culture, and maintained for 24 or 48 hr in F-12 defined medium equilibrated with 95% O2 and 5% CO2. Some ganglia are preincubated for 30 min in medium containing the VIP receptor antagonist VIP(6-28), and then transferred for 24 hr to medium containing both VIP(6-28) and an agonist. In experiments in which cAMP is to be measured, ganglia are removed from animals and preincubated for 30 min in F-12 medium containing 500 μM IBMX to prevent the metabolism of cAMP. Ganglia are then incubated for an additional 30 min in F-12 medium with IBMX and the compound to be studied. When the action of VIP(6-28) is examined, it is added to the medium during the last 5 min of the preincubation and throughout the incubation. Ascorbic acid (0.2 mg/mL) is added to cultures containing isoproterenol to retard oxidation of the catecholamine. No significant differences in peptide levels are detected between ganglia maintained in F-12 alone and those cultured in medium containing ascorbic acid[1].
References	[1]. Mohney RP, et al. Vasoactive intestinal peptide enhances its own expression in sympathetic neurons after injury. J Neurosci. 1998 Jul 15;18(14):5285-93.

Chemical & Physical Properties

Molecular Formula	C₁₂₆H₂₀₇N₃₇O₃₄S
Molecular Weight	2816.28000
Exact Mass	2814.53000
PSA	1247.28000
LogP	5.53550
InChIKey	BVEZAVADHLXCKB-UHFFFAOYSA-N
SMILES	CCC(C)C(NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CC(N)=O)NC(=O)C(CC(=O)O)NC(=O)C(NC(=O)C(N)Cc1ccccc1)C(C)O)C(C)O)C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(N)=O)C(N)=O
Storage condition	-20°C

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

Articles5

Fishbein, V.A., et al.

Peptide 15 , 95, (1994)

Polarized enteric submucosal circuits involved in secretory responses of the guinea-pig proximal colon.

J. Physiol. 506 , 539-550, (1998)

1. Neuronal retrograde tracing with the dye DiI (1,1'-didodecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate), in combination with immunohistochemical detection of choline acetyltransferase (ChAT...

Vasoactive intestinal peptide enhances its own expression in sympathetic neurons after injury.

J. Neurosci. 18 , 5285-5293, (1998)

Neurons in the adult rat superior cervical sympathetic ganglion (SCG) dramatically increase their content of vasoactive intestinal peptide (VIP) and its mRNA after axotomy in vivo and after explantati...

Synonyms

Vasoactive Intestinal Peptide Fragment 6-28 human,porcine,rat

PHE-THR-ASP-ASN-TYR-THR-ARG-LEU-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-ILE-LEU-ASN-NH2

vip 6-28

VIP (6-28) (human, bovine, porcine, rat)

VIP(6-28)(human, rat, porcine, bovine)

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