Introduction：Basic information about CAS 145915-60-2|CGP 53353, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | CGP 53353 |
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| CAS Number | 145915-60-2 | Molecular Weight | 365.33 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C20H13F2N3O2 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | / |
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Names
| Name | 5,6-bis(4-fluoroanilino)isoindole-1,3-dione |
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| Synonym | More Synonyms |
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CGP 53353 BiologicalActivity
| Description | CGP-53353 (DAPH-7) is an potent PKC inhibitor with IC50s of 0.41 mM and 3.8 mM for PKCβII and PKCβI, respectively. CGP-53353 can inhibit glucose-induced cell proliferation and DNA synthesis in AoSMC and A10 cells. CGP-53353 can be used for researching atherosclerosis of diabetic patients[1]. |
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| Related Catalog | Signaling Pathways >>Epigenetics >>PKCResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisResearch Areas >>Metabolic DiseaseSignaling Pathways >>TGF-beta/Smad >>PKC |
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| Target | PKCβII:0.41 mM (IC50) PKCβI:3.8 mM (IC50) |
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| In Vitro | CGP-53353 (DAPH-7) (1 μM; 48-96 hours) inhibits glucose-induced cell proliferation in A10 cells[1]. CGP-53353 (1 μM ; 0-48 hours) inhibits the glucose-induced increase and acceleration of DNA synthesis in A10, also blocks the glucose-induced increase of S-phase cell percentage[1]. Cell Proliferation Assay Cell Line: A10 (cell proliferation induced by glucose)[1] Concentration: 1 μM Incubation Time: 48-96 hours Result: Inhibited glucose-induced cell proliferation, although A10 cell proliferation was stimulated by increasing glucose concentrations. |
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| References | [1]. Yamamoto M, et al. Acute glucose-induced downregulation of PKC-betaII accelerates cultured VSMC proliferation. Am J Physiol Cell Physiol. 2000;279(3):C587-C595. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Molecular Formula | C20H13F2N3O2 |
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| Molecular Weight | 365.33 |
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| Exact Mass | 365.097595 |
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| PSA | 70.23000 |
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| LogP | 3.89 |
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| Index of Refraction | 1.703 |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Synonyms
| CGP 53 353 |
| DAPH 2 |
| 5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione DAPH 2 |
| PKCbetaII/EGFR Inhibitor |
| 1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]- |
| 4,5-bis(4-fluoroanilino)phthalimide |
| 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE |
| Pam2CSK4 Biotin |
