Introduction：Basic information about CAS 220673-95-0|(D-Phe11,His12)-Sauvagine (11-40), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (D-Phe11,His12)-Sauvagine (11-40) |
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| CAS Number | 220673-95-0 | Molecular Weight | 3651.24000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C161H274N48O46S | Melting Point | / |
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| MSDS | USA | Flash Point | / |
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Names
| Name | Antisauvagine-30 |
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| Synonym | More Synonyms |
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(D-Phe11,His12)-Sauvagine (11-40) BiologicalActivity
| Description | Antisauvagine-30 (aSvg-30) is a potent, competitive and selective CRF2 receptor antagonist with Kd values of 1.4 nM and 153.6 nM for mouse CRF2β and rat CRF1 receptors, respectively[1]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>CRFRResearch Areas >>Neurological Disease |
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| Target | Kd: 1.4 nM (mouse CRF2β) ;Kd: 153.6 nM (rat CRF1)[1] |
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| References | [1]. O Brauns, et al. Pharmacological and chemical properties of astressin, antisauvagine-30 and alpha-helCRF: significance for behavioral experiments. Neuropharmacology. 2001 Sep;41(4):507-16. [2]. Farahnaz Sananbenesi, et al. Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: a possible link between stress and fear memory. J Neurosci |
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Chemical & Physical Properties
| Molecular Formula | C161H274N48O46S |
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| Molecular Weight | 3651.24000 |
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| Exact Mass | 3649.01000 |
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| PSA | 1611.26000 |
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| LogP | 8.45320 |
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| InChIKey | JDWSXVUWDQFRCE-JBNJRNGTSA-N |
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| SMILES | CCC(C)C(NC(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)O)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)O)NC(=O)C(NC(=O)C(CCC(=O)O)NC(=O)C(NC(=O)C(CCSC)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(N)Cc1ccccc1)C(C)CC)C(C)CC)C(C)O)C(=O)O |
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Safety Information
| Safety Phrases | 22-24/25 |
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| WGK Germany | 3 |
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Synonyms
| H-D-Phe-His-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2 |
| D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ILE-NH2 |
| H-D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THE-ILE-OH |
| M.W. 3650.29 C161H274N48O46S |
| Antisauvagine 30 |
