CAS 182485-36-5|TPMPA

Introduction：Basic information about CAS 182485-36-5|TPMPA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. TPMPA BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	TPMPA
CAS Number	182485-36-5	Molecular Weight	161.13900
Density	/	Boiling Point	/
Molecular Formula	C₆H₁₂NO₂P	Melting Point	/
MSDS	Chinese	Flash Point	/

Names

Name	(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate
Synonym	More Synonyms

TPMPA BiologicalActivity

Description	TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM). TPMPA has the potential for the research of suppressing orientation selectivity in ganglion cells[1][2][3].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor
Target	KB: 2.1 μM (GABAC)
In Vitro	TPMPA antagonizes the GABA currents of ρ1 receptors (IC50 = 1.6 μM) and those of the chimeric ρ1/α1 receptors with approximately the same potency (IC50 = 1.3 μM)[1]. TPMPA shows weak activity against rho-1 and rho-2 receptors, with the KB values of 2.0 and 15.6 μM, respectively[2]
References	[1]. Martínez-Torres A, et al. GABArho 1/GABAAalpha 1 receptor chimeras to study receptor desensitization. Proc Natl Acad Sci U S A. 2000;97(7):3562-3566. [2]. Graham A. R. Johnston, et al. Neurologically-active compounds. WO1998058939A1 [3]. Johnston GA. GABAc receptors: relatively simple transmitter -gated ion channels?. Trends Pharmacol Sci. 1996;17(9):319-323.

Chemical & Physical Properties

Molecular Formula	C₆H₁₂NO₂P
Molecular Weight	161.13900
Exact Mass	161.06100
PSA	59.14000
LogP	1.09260
InChIKey	MFUKVPOVVKKLRQ-UHFFFAOYSA-N
SMILES	CP(=O)(O)C1=CCNCC1

Safety Information

WGK Germany	3

Synonyms

(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinicacid

TPMPA hydrate

TPMPA

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