Introduction：Basic information about CAS 72141-57-2|Losulazine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Losulazine |
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| CAS Number | 72141-57-2 | Molecular Weight | 558.54700 |
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| Density | 1.454g/cm3 | Boiling Point | 695.7ºC at 760 mmHg |
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| Molecular Formula | C27H22F4N4O3S | Melting Point | / |
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| MSDS | / | Flash Point | 374.5ºC |
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Names
| Name | [4-(4-fluorophenyl)sulfonylpiperazin-1-yl]-[4-[[7-(trifluoromethyl)quinolin-4-yl]amino]phenyl]methanone |
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| Synonym | More Synonyms |
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Chemical & Physical Properties
| Density | 1.454g/cm3 |
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| Boiling Point | 695.7ºC at 760 mmHg |
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| Molecular Formula | C27H22F4N4O3S |
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| Molecular Weight | 558.54700 |
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| Flash Point | 374.5ºC |
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| Exact Mass | 558.13500 |
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| PSA | 90.99000 |
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| LogP | 6.31260 |
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| Index of Refraction | 1.638 |
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| InChIKey | SYJKIRZBDWNJSB-UHFFFAOYSA-N |
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| SMILES | O=C(c1ccc(Nc2ccnc3cc(C(F)(F)F)ccc23)cc1)N1CCN(S(=O)(=O)c2ccc(F)cc2)CC1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- TM0829800
- CHEMICAL NAME :
- Piperazine, 1-((4-fluorophenyl)sulfonyl)-4-(4-((7-(trifluoromethy l)-4-quinolinyl)amino) benzoyl)-
- CAS REGISTRY NUMBER :
- 72141-57-2
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C27-H22-F4-N4-O3-S
- MOLECULAR WEIGHT :
- 558.59
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >3160 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 29,133,1986 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 168 mg/kg
- SEX/DURATION :
- lactating female 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - physical
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 33,36C,1986
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Synonyms
| Losulazina |
| Losulazine |
| Losulazinum |
