CAS 33818-15-4|Citicoline sodium salt
| Common Name | Citicoline sodium salt | ||
|---|---|---|---|
| CAS Number | 33818-15-4 | Molecular Weight | 511.31 |
| Density | / | Boiling Point | / |
| Molecular Formula | C14H26N4NaO11P2 | Melting Point | 259-268°C (dec.) |
| MSDS | USA | Flash Point | / |
Names
| Name | Cytidine 5′-diphosphocholine sodium salt dihydrate |
|---|---|
| Synonym | More Synonyms |
Citicoline sodium salt BiologicalActivity
| Description | Cytidoline sodium salt is an intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes and also exerts neuroprotective effects. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
| References | [1]. Davinelli S, et al. Cytoprotective Effects of Citicoline and Homotaurine against Glutamate and High Glucose Neurotoxicity in Primary Cultured Retinal Cells. Oxid Med Cell Longev. 2017;2017:2825703. [2]. Karpova MN, et al. Increase of the seizure threshold in C57BL/6 mice after citicoline administration. Bull Exp Biol Med. 2015 Jan;158(3):315-7. |
Chemical & Physical Properties
| Melting Point | 259-268°C (dec.) |
|---|---|
| Molecular Formula | C14H26N4NaO11P2 |
| Molecular Weight | 511.31 |
| PSA | 238.17000 |
| InChIKey | YWAFNFGRBBBSPD-OCMLZEEQSA-M |
| SMILES | C[N+](C)(C)CCOP(=O)([O-])OP(=O)([O-])OCC1OC(n2ccc(N)nc2=O)C(O)C1O.[Na+] |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles4
More Articles| Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo. Br. J. Cancer 111(2) , 318-25, (2014) The modest benefits of gemcitabine (dFdC) therapy in patients with pancreatic ductal adenocarcinoma (PDAC) are well documented, with drug delivery and metabolic lability cited as important contributin... | |
| A randomized dose-response trial of citicoline in acute ischemic stroke patients. Citicoline Stroke Study Group. Neurology 49 , 671-678, (1997) Citicoline (CDP-choline) is a key intermediary in the biosynthesis of phosphatidylcholine, an important component of the neural cell membrane. It has been shown to produce beneficial effects in both a... | |
| Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats. Stroke 28 , 1060-1065, (1997) Citicoline, a naturally occurring precursor of phosphatidylcholine, is neuroprotective and is currently being assessed in clinical trials. To evaluate potential synergistic neuroprotective effects of ... |
Synonyms
| Cytidine, 5'-O-[hydroxy[[hydroxy[2-(trimethylammonio)ethoxy]phosphinyl]oxy]phosphinyl]-, inner salt, sodium salt (1:1) |
| EINECS 251-689-1 |
| Neuroton |
| CITICOLINE SODIUM SALT |
| MFCD00150508 |
| Cytidine 5‘-diphosphocholine sodium salt hydrate |
| Choline Hydroxide 5'-Ester with Cytidine 5'-(Sodium Dihydrogen Diphosphate) Inner Salt |
| CDP-choline-Na |
| Citicoline Sodium |
| Cytidine 5'-(Trihydrogen Diphosphate) P'-(2-(Trimethylammonio)ethyl) Ester Inner Salt Monosodium Salt |
| Cytidine 5′-diphosphocholine sodium salt |
| Sodium 5'-O-[({[2-(trimethylammonio)ethoxy]phosphinato}oxy)phosphinato]cytidine |
| Citicoline sodium salt hydrate |
| Cidifos |
| Cytidine 5'-(Trihydrogen Diphosphate) Mono(2-(trimethylammonio)ethyl) Ester Hydroxide Inner Salt Monosodium Salt |
