CAS 643-84-5|Malvidin chloride

Introduction：Basic information about CAS 643-84-5|Malvidin chloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Malvidin chloride BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles32
8. Synonyms

Common Name	Malvidin chloride
CAS Number	643-84-5	Molecular Weight	366.75000
Density	1.183 g/mL at 25 °C(lit.)	Boiling Point	66-67 °C(lit.)
Molecular Formula	C₁₇H₁₅ClO₇	Melting Point	/
MSDS	ChineseUSA	Flash Point	30 °F

Names

Name	Malvidin chloride
Synonym	More Synonyms

Malvidin chloride BiologicalActivity

Description	Malvidin (chloride) is a bioactive compound isolated from Oryza sativacv. Heugjinjubyeo. Malvidin shows cytotoxicity through the arrest of the G2/M phase of cell cycle and induction of apoptosis. Malvidin can be used for the research of cancer[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Others >>Others
In Vitro	Malvidin (0~80 μg/mL; 96 hours; U937 cells) shows cytotoxic activity in a dose-dependent pattern[1]. The IC50 value of Malvidin for U937 cells is 40 μg/mL. Malvidin (U937 cells) shows arrest at the G2/M phase of the cell cycle and increases sub G1 hypo-diploid population[1]. Cell Viability Assay[1] Cell Line: U937 cells Concentration: 0~80 μg/mL Incubation Time: 96 hours Result: Showed cytotoxic activity in a dose-dependent pattern.
References	[1]. Jin W H, et al. Cyanidin and Malvidin fromOryza sativacv. HeugjinjubyeoMediate Cytotoxicity against Human Monocytic Leukemia Cellsby Arrest of G2/M Phase and Induction of Apoptosis. J. Agric. Food Chem. 2004, 52, 8, 2213–2217

Chemical & Physical Properties

Density	1.183 g/mL at 25 °C(lit.)
Boiling Point	66-67 °C(lit.)
Molecular Formula	C₁₇H₁₅ClO₇
Molecular Weight	366.75000
Flash Point	30 °F
Exact Mass	366.05100
PSA	112.52000
LogP	0.22450
Index of Refraction	n20/D 1.335(lit.)
InChIKey	KQIKOUUKQBTQBE-UHFFFAOYSA-N
SMILES	COc1cc(-c2[o+]c3cc(O)cc(O)c3cc2O)cc(OC)c1O.[Cl-]
Storage condition	?20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK9900000

CHEMICAL NAME :: Flavylium, 3,4',5,7-tetrahydroxy-3',5'-dimethoxy-, chloride

CAS REGISTRY NUMBER :: 643-84-5

LAST UPDATED :: 198912

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H15-O7.Cl

MOLECULAR WEIGHT :: 366.77

WISWESSER LINE NOTATION :: T66 BOJ CR DQ CO1 EO1& DQ GQ IQ &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01634 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3 gm/kg

SEX/DURATION :: male 60 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O., Bangalore 560 080, India) V.1- 1932- Volume(issue)/page/year: 57,1354,1988

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LK9900000
HS Code	2909499000

Customs

HS Code	2909499000
Summary	2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles32

A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia.

Fitoterapia 98 , 11-21, (2014)

The alpha7 nicotinic acetylcholine receptor (nAChR) is a potential target in neuroinflammation. Screening a plant extract library identified Solidago nemoralis as containing methyl-quercetin derivativ...

How subtle is the "terroir" effect? Chemistry-related signatures of two "climats de Bourgogne".

PLoS ONE 9(5) , e97615, (2014)

The chemical composition of grape berries is influenced by various environmental conditions often considered to be representative of a "terroir". If grapes from a given terroir are assumed to reflect ...

Direct and indirect inactivation of tumor cell protective catalase by salicylic acid and anthocyanidins reactivates intercellular ROS signaling and allows for synergistic effects.

Carcinogenesis 36(3) , 400-11, (2015)

Salicylic acid and anthocyanidins are known as plant-derived antioxidants, but also can provoke paradoxically seeming prooxidant effects in vitro. These prooxidant effects are connected to the potenti...

Synonyms

MFCD00017585

2-(4-hydroxy-3,5-dimethoxyphenyl)chromenylium-3,5,7-triol,chloride

EINECS 211-403-8

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