Introduction：Basic information about CAS 183204-72-0|Tipiracil hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tipiracil hydrochloride |
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| CAS Number | 183204-72-0 | Molecular Weight | 279.123 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C9H12Cl2N4O2 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | / |
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Names
| Name | 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dione,hydrochloride |
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| Synonym | More Synonyms |
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Tipiracil hydrochloride BiologicalActivity
| Description | Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research. |
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| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/AnalogResearch Areas >>Cancer |
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| In Vitro | Tipiracil has antiangiogenic effect, and inhibits proliferation of endothelial cells[1]. Tipiracil is a potent inhibitor of thymidine phosphorylase, which is the enzyme that degrades FTD[2]. |
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| References | [1]. Peters GJ, et al. TAS-102: more than an antimetabolite. Lancet Oncol. 2012 Dec;13(12):e518-9. [2]. Yoshino T, et al. TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial. Lancet Oncol. 2012 Oct;13(10):993-1001. |
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Chemical & Physical Properties
| Molecular Formula | C9H12Cl2N4O2 |
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| Molecular Weight | 279.123 |
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| Exact Mass | 278.033722 |
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| PSA | 93.33000 |
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| LogP | 1.95390 |
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| InChIKey | KGHYQYACJRXCAT-UHFFFAOYSA-N |
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| SMILES | Cl.N=C1CCCN1Cc1[nH]c(=O)[nH]c(=O)c1Cl |
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| Storage condition | 2-8°C |
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| Tipiracil HCl |
| 5-amino-1-[(5-chloro-2,6-dihydroxypyrimidin-4-yl)methyl]-3,4-dihydro-2H-pyrrolium chloride |
| 2,4(1H,3H)-Pyrimidinedione, 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-, hydrochloride (1:1) |
| TAS-1-462 |
| Tipiracil hydrochloride |
| 2H-pyrrolium, 5-amino-1-[(5-chloro-2,6-dihydroxy-4-pyrimidinyl)methyl]-3,4-dihydro-, chloride (1:1) |
| 5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione hydrochloride (1:1) |
| Tipiracil hydrochloride (JAN) |
