Introduction：Basic information about CAS 37717-21-8|Flurocitabine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Flurocitabine |
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| CAS Number | 37717-21-8 | Molecular Weight | 243.19200 |
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| Density | 2.11g/cm3 | Boiling Point | 391.7ºC at 760mmHg |
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| Molecular Formula | C9H10FN3O4 | Melting Point | / |
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| MSDS | / | Flash Point | 190.7ºC |
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Names
| Name | Flurocitabine |
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| Synonym | More Synonyms |
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Flurocitabine BiologicalActivity
| Description | Flurocitabine is a fluorinated anlydride analog of cytosine arabinoside, partially hydrolysecl in vivo into two active antitumor substances (arabinosyl-tluorocytosine (ara-FC) and arabinosyl-fluorouracil (ara-FU)). Flurocitabine has antitumor activity during phase I studies in acute leukemia and solid tumors[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/Analog |
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| References | [1]. Alberto P, et al. Phase II study of anhydro-ara-5-fluorocytidine in adenocarcinoma of gastrointestinal tract, epidermoid carcinoma of lung, head and neck, breast carcinoma and small cell anaplastic carcinoma of lung. A study report of the E.O.R.T.C. early clinical trial cooperative group. Eur J Cancer. 1978;14(2):195-201. |
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Chemical & Physical Properties
| Density | 2.11g/cm3 |
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| Boiling Point | 391.7ºC at 760mmHg |
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| Molecular Formula | C9H10FN3O4 |
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| Molecular Weight | 243.19200 |
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| Flash Point | 190.7ºC |
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| Exact Mass | 243.06600 |
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| PSA | 100.59000 |
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| Index of Refraction | 1.813 |
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| InChIKey | PAYBYKKERMGTSS-MNCSTQPFSA-N |
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| SMILES | N=c1nc2n(cc1F)C1OC(CO)C(O)C1O2 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- HA5400000
- CHEMICAL NAME :
- Cytosine, 2,2'-anhydroarabino-5-fluoro-
- CAS REGISTRY NUMBER :
- 37717-21-8
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C9-H10-F-N3-O4
- MOLECULAR WEIGHT :
- 243.22
- WISWESSER LINE NOTATION :
- T B556 AN CO GO IN HHTT&J D1Q EQ JZ KF
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 33 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Blood - normocytic anemia Blood - leukopenia
MUTATION DATA - TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - mouse Leukocyte
- DOSE/DURATION :
- 1 mmol/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 23,2657,1974
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Synonyms
| 5-fluoro-arabino-O2,O2'-cyclocytidine |
| Ro-21-0702 |
| fluoroancitabine |
| 5-Fluoro-2,2'-cyclocytidine |
| 5-fluoro-arabino-2,2'-anhydro-cytidine |
| Fluorocitabin |
| 5-Fluor-2,2'-cyclocytidin |
| AAFC |
