Introduction：Basic information about CAS 65101-87-3|Nanchangmycin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Nanchangmycin |
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| CAS Number | 65101-87-3 | Molecular Weight | 889.10 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C47H77NaO14 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Dianemycin, monosodium salt |
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| Synonym | More Synonyms |
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Nanchangmycin BiologicalActivity
| Description | Nanchangmycin, produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>InfectionNatural Products >>Others |
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| Target | Bacteria[1] Zika virus[2] |
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| In Vitro | Nanchangmycin can be used as a growth promotant in poultry and to cure coccidiosis in chickens. Nanchangmycin is active against drug resistant strains of malaria[1]. Nanchangmycin as a potent inhibitor of Zika virus (ZIKV) entry across all cell types tested including physiologically relevant primary cells. Nanchangmycin potently reduces infection of all three strains of ZIKV across all three cell types. The IC50s for infection are between 0.1 and 0.4 μM while Nanchangmycin has low toxicity in these ranges. In addition, DENV is inhibited by Nanchangmycin across cell types[2]. |
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| References | [1]. Liu T et al. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin. Chem Biol. 2008 May;15(5):449-58. [2]. Rausch K, et al. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 2017 Jan 17;18(3):804-815. |
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Chemical & Physical Properties
| Molecular Formula | C47H77NaO14 |
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| Molecular Weight | 889.10 |
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| PSA | 188.90000 |
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| LogP | 6.14960 |
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| InChIKey | XMAIRYYXDCNFKP-DYTQFKGPSA-M |
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| SMILES | COC1CCC(OC2CC(C3(C)CCC4(CC(O)C(C)C(C(C)C=C(C)C(=O)C(C)CC(C)C(=O)[O-])O4)O3)OC3(OC(C4OC(O)(CO)C(C)CC4C)CC3C)C2C)OC1C.[Na+] |
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| Storage condition | -20℃ |
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Synonyms
