CAS 474-67-9|Ergosta-5,22-dien-3β-ol
| Common Name | Ergosta-5,22-dien-3β-ol | ||
|---|---|---|---|
| CAS Number | 474-67-9 | Molecular Weight | 398.664 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 488.7±14.0 °C at 760 mmHg |
| Molecular Formula | C28H46O | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 213.3±12.4 °C |
Names
| Name | Brassicasterol |
|---|---|
| Synonym | More Synonyms |
Ergosta-5,22-dien-3β-ol BiologicalActivity
| Description | Brassicasterol, a metabolite of Ergosterol, plays a role in the inhibitory effect on bladder carcinogenesis promotion via androgen signaling[1]. Brassicasterol shows dual anti-infective properties against HSV-1 (IC50=1.2 µM) and Mycobacterium tuberculosis, and cardiovascular protective effect[2]. Brassicasterol exerts an anti-cancer effect by dual-targeting AKT and androgen receptor signaling in prostate cancer[3]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Anti-infection >>HSVResearch Areas >>InfectionSignaling Pathways >>Others >>Androgen ReceptorSignaling Pathways >>Anti-infection >>Bacterial |
| References | [1]. Yasuharu Yazawa, et al. Inhibitory effect of ergosterol on bladder carcinogenesis is due to androgen signaling inhibition by brassicasterol, a metabolite of ergosterol. J Nat Med. 2020 Sep;74(4):680-688. [2]. Sherif T S Hassan. Brassicasterol with Dual Anti-Infective Properties against HSV-1 and Mycobacterium tuberculosis, and Cardiovascular Protective Effect: Nonclinical In Vitro and In Silico Assessments. Biomedicines. 2020 May 24;8(5):132. [3]. Yinzhu Xu, et al. Brassicasterol from Edible Aquacultural Hippocampus abdominalis Exerts an Anti-Cancer Effect by Dual-Targeting AKT and AR Signaling in Prostate Cancer. Biomedicines. 2020 Sep 22;8(9):370. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 488.7±14.0 °C at 760 mmHg |
| Molecular Formula | C28H46O |
| Molecular Weight | 398.664 |
| Flash Point | 213.3±12.4 °C |
| Exact Mass | 398.354858 |
| PSA | 20.23000 |
| LogP | 9.68 |
| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
| Index of Refraction | 1.532 |
| InChIKey | OILXMJHPFNGGTO-ZAUYPBDWSA-N |
| SMILES | CC(C)C(C)C=CC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C |
| Storage condition | 2-8°C |
Safety Information
| RIDADR | NONH for all modes of transport |
|---|
Articles7
More Articles| The plant sterol brassicasterol as additional CSF biomarker in Alzheimer's disease. Acta Psychiatr. Scand. 124 , 184-192, (2011) Plant sterols (sitosterol, campesterol, stigmasterol and brassicasterol) are solely dietary-derivable sterols that are structurally very similar to cholesterol. In contrast to peripheral cholesterol, ... | |
| Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. Curr. Gerontol. Geriatr. Res. , doi: 10.1155/2012/179318, (2012) Over the past 15 years, insights into sterol metabolism have improved our understanding of the relationship between lipids and common conditions such as atherosclerosis and Alzheimer's Disease (AD). A... | |
| Fatty acid and sterol composition of frozen and freeze-dried New Zealand Green Lipped Mussel (Perna canaliculus) from three sites in New Zealand. Asia Pac. J. Clin. Nutr. 12 , 50-60, (2003) In view of previously reported anti-inflammatory bioactivity of the New Zealand Green Lipped Mussel (NZGLM), the overall lipid profile and fatty acid and sterol composition of the NZGLM from various s... |
Synonyms
| EINECS 207-486-5 |
| Ergosta-5,22-dien-3β-ol, (24R)- |
| (3S,8S,9S,10R,13R,14S,17R)-17-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol |
| Ergosta-5,22-dien-3β-ol |
| (3β,22E)-Ergosta-5,22-dien-3-ol |
| Ergosta-5,22-dien-3-ol, (3β,22E)- |
