CAS 1897-45-6|Chlorothalonil
Introduction：Basic information about CAS 1897-45-6|Chlorothalonil, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Chlorothalonil | ||
|---|---|---|---|
| CAS Number | 1897-45-6 | Molecular Weight | 265.911 |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 350.5±37.0 °C at 760 mmHg |
| Molecular Formula | C8Cl4N2 | Melting Point | 250-251ºC |
| MSDS | ChineseUSA | Flash Point | 153.8±20.7 °C |
| Symbol | GHS05, GHS06, GHS08, GHS09 | Signal Word | Danger |
Names
| Name | chlorothalonil |
|---|---|
| Synonym | More Synonyms |
Chlorothalonil BiologicalActivity
| Description | Chlorothalonil is a broad spectrum fungicide and is effective in protecting plants against fungal diseases caused mainly by Phytophthora infestans and Alternaria solani. Chlorothalonil is used for controlling of fungal foliar diseases of vegetables and crops[1][2]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Fungal |
| References | [1]. Pengfei Zhang, et al. Low Dose Chlorothalonil Impairs Mouse Spermatogenesis Through the Intertwining of Estrogen Receptor Pathways With Histone and DNA Methylation.Chemosphere. 2019 Sep;230:384-395. [2]. Małgorzata Baćmaga, et al. The Influence of Chlorothalonil on the Activity of Soil Microorganisms and Enzymes. Ecotoxicology. 2018 Nov;27(9):1188-1202. |
Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 350.5±37.0 °C at 760 mmHg |
| Melting Point | 250-251ºC |
| Molecular Formula | C8Cl4N2 |
| Molecular Weight | 265.911 |
| Flash Point | 153.8±20.7 °C |
| Exact Mass | 263.881561 |
| PSA | 47.58000 |
| LogP | 2.88 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.633 |
| InChIKey | CRQQGFGUEAVUIL-UHFFFAOYSA-N |
| SMILES | N#Cc1c(Cl)c(Cl)c(Cl)c(C#N)c1Cl |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 310 mg/m3/1H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2500 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6750 mg/kg/90D-C
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 142 gm/kg/80W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors
MUTATION DATA - TEST SYSTEM :
- Fish - not otherwise specified
- DOSE/DURATION :
- 1400 ppt/7D (Continuous)
- REFERENCE :
- HYHPDO Hunan Yixueyuan Xuebao. Journal of Hunan Medical College. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known. Volume(issue)/page/year: 12,153,1987 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 30,319,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 30,319,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1833 No. of Facilities: 3268 (estimated) No. of Industries: 21 No. of Occupations: 26 No. of Employees: 62724 (estimated) No. of Female Employees: 6716 (estimated)
- TEST SYSTEM :
- Fish - not otherwise specified
- DOSE/DURATION :
- 1400 ppt/7D (Continuous)
- REFERENCE :
- HYHPDO Hunan Yixueyuan Xuebao. Journal of Hunan Medical College. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known. Volume(issue)/page/year: 12,153,1987 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 30,319,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 30,319,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1833 No. of Facilities: 3268 (estimated) No. of Industries: 21 No. of Occupations: 26 No. of Employees: 62724 (estimated) No. of Female Employees: 6716 (estimated)
Safety Information
| Symbol | GHS05, GHS06, GHS08, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H317-H318-H330-H335-H351-H410 |
| Precautionary Statements | P260-P273-P280-P284-P304 + P340 + P310 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | T+;N |
| Risk Phrases | R26;R37;R40;R41;R43;R50/53 |
| Safety Phrases | S28-S36/37/39-S45-S60-S61-S36/37-S26 |
| RIDADR | 3276 |
| RTECS | NT2600000 |
| Packaging Group | I |
| Hazard Class | 6.1(a) |
| HS Code | 2926909090 |
Customs
| HS Code | 2926909038 |
|---|---|
| Summary | HS: 2926909038 fenoxanil Educational tariff:17.0% Tax rebate rate:9.0% Regulatory conditions:S(Registration certificate of import and export) Lowest tariff:6.5% General tariff:30.0% |
Articles38
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| Photoreduction of chlorothalonil fungicide on plant leaf models. Environ. Sci. Technol. 45(22) , 9582-9, (2011) Photodegradation is seldom considered at the surface of vegetation after crop spraying. Chlorothalonil, a broad-spectrum foliar fungicide with a very widespread use worldwide, was considered. To repre... |
Synonyms
| meta-TCPN |
| 2,4,5,6-Tetrachloroisophthalonitrile |
| Chloroalonil |
| MFCD00045594 |
| 2,4-Dicyanotetrachlorobenzene |
| 1,3-dicyano-2,4,5,6-tetrachlorobenzene |
| 2,4,5,6-tetrachlorobenzene-1,3-dicarbonitrile |
| 2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile |
| m-Tcpn |
| 2,4,5,6-tetrachloro-1,3-dicyanobenzene |
| Nopcocide |
| TPN |
| Perchloroisophthalonitrile |
| 2,4,5,6-tetrachloroisophthalodinitrile |
| Chlorothalonil |
| EINECS 217-588-1 |
| tetrachloroisophthalonitrile |
| Bravo |
| Daconil |
| 1,3-Benzenedicarbonitrile, 2,4,5,6-tetrachloro- |
| Tetrachloroisophthalodinitrile |
| 1,3-dicyanotetrachlorobenzene |
