Introduction：Basic information about CAS 347396-82-1|Ranibizumab (anti-VEGF), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ranibizumab (anti-VEGF) |
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| CAS Number | 347396-82-1 | Molecular Weight | / |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C2158H3282N562O681S12 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Ranibizumab |
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| Synonym | More Synonyms |
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Ranibizumab (anti-VEGF) BiologicalActivity
| Description | Ranibizumab (RG-6321) (anti-VEGF) is a humanized anti-VEGF monoclonal antibody fragment and can recognize all VEGF-A isoforms (VEGF110, VEGF121, and VEGF165)[1]. Ranibizumab (anti-VEGF) slows vision loss in vivo and is used for wet age-related macular degeneration (AMD) research[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Protein Tyrosine Kinase/RTK >>VEGFR |
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| In Vitro | Ranibizumab (RG-6321) is a humanized anti-VEGF monoclonal antibody fragment (IgG antigen-binding fragment (Fab-Y0317)[2]. Ranibizumab (0.0625-0.25 mg/ml; 72 hours) results in increased necrosis and apoptosis at in rat retinal cell cultures[3]. |
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| In Vivo | Studies in monkeys demonstrates that after a single intravitreal administration, Ranibizumab can distribute rapidly to the retina (6–24 h). Ranibizumab can rapidly penetrate through the retina to reach the choroid, just 1 h after intravitreal administration in rabbits[1]. In a study comparing the pharmacokinetics of 0.5 mg of intravitreal Ranibizumab with 1.25 mg of intravitreal Bevacizumab in the rabbit, the vitreous half-life of Ranibizumab is 2.88 days, shorter than the Bevacizumab half-life of 4.32 days. Peak concentrations in the aqueous humor of the treated eye at 3 days following treatment are 37.7 μg/ml for Bevacizumab and 17.9 μg/ml for Ranibizumab, respectively[1]. |
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Chemical & Physical Properties
| Molecular Formula | C2158H3282N562O681S12 |
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Synonyms
