Introduction：Basic information about CAS 4584-46-7|(2-Chloroethyl)dimethylamine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (2-Chloroethyl)dimethylamine hydrochloride |
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| CAS Number | 4584-46-7 | Molecular Weight | 144.043 |
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| Density | / | Boiling Point | 57.8ºC at 760 mmHg |
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| Molecular Formula | C4H11Cl2N | Melting Point | 201-204 °C(lit.) |
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| MSDS | ChineseUSA | Flash Point | 21.6ºC |
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| Symbol |
GHS06 | Signal Word | Danger |
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Names
| Name | 2-Dimethylaminoethyl chloride hydrochloride |
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| Synonym | More Synonyms |
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Chemical & Physical Properties
| Boiling Point | 57.8ºC at 760 mmHg |
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| Melting Point | 201-204 °C(lit.) |
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| Molecular Formula | C4H11Cl2N |
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| Molecular Weight | 144.043 |
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| Flash Point | 21.6ºC |
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| Exact Mass | 143.026855 |
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| PSA | 3.24000 |
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| LogP | 1.58880 |
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| InChIKey | LQLJZSJKRYTKTP-UHFFFAOYSA-N |
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| SMILES | CN(C)CCCl.Cl |
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| Water Solubility | 2000 g/L (20 ºC) |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- KQ9020000
- CHEMICAL NAME :
- Ethylamine, 2-chloro-N,N-dimethyl-, hydrochloride
- CAS REGISTRY NUMBER :
- 4584-46-7
- LAST UPDATED :
- 199804
- DATA ITEMS CITED :
- 17
- MOLECULAR FORMULA :
- C4-H10-Cl-N.Cl-H
- MOLECULAR WEIGHT :
- 144.06
- WISWESSER LINE NOTATION :
- G2N1&1 &GH
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 238 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 280 mg/kg
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes Gastrointestinal - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 290 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Blood - hemorrhage Skin and Appendages - dermatitis, other (after systemic exposure)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 117 mg/kg/7D-I
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Liver - hepatitis (hepatocellular necrosis), diffuse Nutritional and Gross Metabolic - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 720 mg/kg/8W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA - TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - rat Cells - not otherwise specified
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,1697,1987
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Safety Information
| Symbol |
GHS06 |
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| Signal Word | Danger |
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| Hazard Statements | H301-H311-H315-H319-H335 |
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| Precautionary Statements | P261-P280-P301 + P310-P305 + P351 + P338-P312 |
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| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
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| Hazard Codes | T+:Verytoxic;N:Dangerous for the environment; |
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| Risk Phrases | R22;R24;R26;R36/37/38;R51/53;R68 |
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| Safety Phrases | S26-S36/37-S45-S61-S36/37/39-S28A |
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| RIDADR | UN 2811 6.1/PG 3 |
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| WGK Germany | 3 |
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| RTECS | KQ9020000 |
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| Packaging Group | III |
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| Hazard Class | 6.1 |
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| HS Code | 29211980 |
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Customs
| HS Code | 2921199090 |
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| Summary | 2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| N-(2-chloroethyl)-N,N-dimethylamine hydrochloride |
| DMC-HCl |
| MFCD00012516 |
| (β-Chloroethyl)dimethylamine hydrochloride |
| 2-(dimethylamino)-ethylchloride hydrochloride |
| N,N-Dimethyl-2-ChloroethylamineHCl |
| 2-(N,N-dimethylamino)ethylchloride hydrochloride |
| DIMETHYLAMINOETHYLCHLORIDE HCL |
| DMC |
| 2-Chloro-N,N-dimethylethanamine hydrochloride (1:1) |
| Ethanamine, 2-chloro-N,N-dimethyl-, hydrochloride (1:1) |
| 2-Chloro-N,N-dimethylethylamine Hydrochloride |
| Dimethyl cyclosiloxane |
| 2-Dimethylaminoethyl chloride hydrochloride |
| 2-dimethylamino-1-chloro-ethane hydrochloride |
| (2-Chloroethyl)dimethylamine hydrochloride |
| N,N-DimethylaminoChloroethaneHCl |
| β-Dimethylaminoethyl chloride hydrochloride |
| 2-chloro-N,N-dimethylaminoethane hydrochloride |
| 2-Dimethylaminoethyl |
| N,N-dimethylamino-2-chloroethane hydrochloride |
| N-(2-Chloroethyl) Dimethyl HCl |
| EINECS 224-970-1 |
| 1-chloro-2-(N,N-dimethylamino)ethane hydrochloride |
| N,N-DIMETHYL(2-CHLOROETHYL)-AMINE |
| 2-Chloro-N,N-dimethylethanamine hydrochloride |
