CAS 970-74-1|(-)-Epigallocatechin(EGC)

Introduction：Basic information about CAS 970-74-1|(-)-Epigallocatechin(EGC), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (-)-Epigallocatechin(EGC) BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Articles51
8. Synonyms

Common Name	(-)-Epigallocatechin(EGC)
CAS Number	970-74-1	Molecular Weight	306.267
Density	1.7±0.1 g/cm3	Boiling Point	685.6±55.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₄O₇	Melting Point	208-210°C
MSDS	ChineseUSA	Flash Point	368.5±31.5 °C

Names

Name	(-)-epigallocatechin
Synonym	More Synonyms

(-)-Epigallocatechin(EGC) BiologicalActivity

Description	(-)-Epigallocatechin is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils.IC50 value:Target: in vitro: EGCG is a potent inhibitor of amyloidogenic cystatin I66Q amyloid fibril formation in vitro. Computational analysis suggests that EGCG prevents amyloidogenic cystatin fibril formation by stabilizing the molecule in its native-like state as opposed to redirecting aggregation to disordered, amorphous aggregates [1]. Combined curcumin and EGCG treatment reduced the cancer stem-like Cluster of differentiation 44 (CD44)-positive cell population. Western blot and immunoprecipitation analyses revealed that curcumin and EGCG specifically inhibited STAT3 phosphorylation and STAT3-NFkB interaction was retained [2]. EGCG exhibited a MIC and MBC of 5μg/mL and 20μg/mL respectively and effectively eradicated E. faecalis biofilms. EGCG induced the formation of hydroxyl radicals in E. faecalis. The addition of DIP protected E. faecalis against EGCG-mediated antibacterial effects. At sub-MIC, EGCG induced significant down-regulation of E. faecalis virulence genes [3].
Related Catalog	Natural Products >>FlavonoidsResearch Areas >>Others
References	[1]. Wang N, et al. (-)-Epigallocatechin-3-gallate Inhibits Fibrillogenesis of Chicken Cystatin. J Agric Food Chem. 2015 Jan 26 [2]. Chung SS, et al. Curcumin and Epigallocatechin Gallate Inhibit the Cancer Stem Cell Phenotype via Down-regulation of STAT3-NFκB Signaling. Anticancer Res. 2015 Jan;35(1):39-46. [3]. Lee P, et al. Effects of Epigallocatechin gallate against Enterococcus faecalis biofilm and virulence. Arch Oral Biol. 2015 Mar;60(3):393-9.

Description

(-)-Epigallocatechin is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils.IC50 value:Target: in vitro: EGCG is a potent inhibitor of amyloidogenic cystatin I66Q amyloid fibril formation in vitro. Computational analysis suggests that EGCG prevents amyloidogenic cystatin fibril formation by stabilizing the molecule in its native-like state as opposed to redirecting aggregation to disordered, amorphous aggregates [1]. Combined curcumin and EGCG treatment reduced the cancer stem-like Cluster of differentiation 44 (CD44)-positive cell population. Western blot and immunoprecipitation analyses revealed that curcumin and EGCG specifically inhibited STAT3 phosphorylation and STAT3-NFkB interaction was retained [2]. EGCG exhibited a MIC and MBC of 5μg/mL and 20μg/mL respectively and effectively eradicated E. faecalis biofilms. EGCG induced the formation of hydroxyl radicals in E. faecalis. The addition of DIP protected E. faecalis against EGCG-mediated antibacterial effects. At sub-MIC, EGCG induced significant down-regulation of E. faecalis virulence genes [3].

Related Catalog

Natural Products >>FlavonoidsResearch Areas >>Others

References

[1]. Wang N, et al. (-)-Epigallocatechin-3-gallate Inhibits Fibrillogenesis of Chicken Cystatin. J Agric Food Chem. 2015 Jan 26

[2]. Chung SS, et al. Curcumin and Epigallocatechin Gallate Inhibit the Cancer Stem Cell Phenotype via Down-regulation of STAT3-NFκB Signaling. Anticancer Res. 2015 Jan;35(1):39-46.

[3]. Lee P, et al. Effects of Epigallocatechin gallate against Enterococcus faecalis biofilm and virulence. Arch Oral Biol. 2015 Mar;60(3):393-9.

Chemical & Physical Properties

Density	1.7±0.1 g/cm3
Boiling Point	685.6±55.0 °C at 760 mmHg
Melting Point	208-210°C
Molecular Formula	C₁₅H₁₄O₇
Molecular Weight	306.267
Flash Point	368.5±31.5 °C
Exact Mass	306.073944
PSA	130.61000
LogP	-0.10
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.776
InChIKey	XMOCLSLCDHWDHP-IUODEOHRSA-N
SMILES	Oc1cc(O)c2c(c1)OC(c1cc(O)c(O)c(O)c1)C(O)C2

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KB5100000

CHEMICAL NAME :: Epigallocatechol

CAS REGISTRY NUMBER :: 970-74-1

LAST UPDATED :: 198912

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H14-O7

MOLECULAR WEIGHT :: 306.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human HeLa cell

DOSE/DURATION :: 25 mg/L

REFERENCE :: PYTCAS Phytochemistry. An International Journal of Plant Biochemistry. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1961- Volume(issue)/page/year: 27,1017,1988

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	KB5100000
HS Code	2932999099

Customs

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles51

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Food Chem. 194 , 495-502, (2015)

Metabolic dysfunction in obesity may be attenuated by whole-grain intake, which has been attributed to synergistic actions of bioactive compounds. Germination/malting may increase grain bioactives, in...

A colourimetric sensor for the simultaneous determination of oxidative status and antioxidant activity on the same membrane: N,N-dimethyl-p-phenylene diamine (DMPD) on Nafion.

Anal. Chim. Acta 865 , 60-70, (2015)

A colourimetric sensor capable of simultaneously measuring oxidative status (OS) in terms of the hazard produced by reactive oxygen species (ROS) and antioxidant activity (AOA) in regard to ROS-scaven...

Identification and quantification of phytochemicals in nutraceutical products from green tea by UHPLC-Orbitrap-MS.

Food Chem. 173 , 607-18, (2014)

A method has been developed and validated for the simultaneous detection and quantification of phytochemicals in nutraceutical products obtained from green tea. For that purpose, ultra-high performanc...

Synonyms

EGC

MFCD00075939

Galloepicatechin

epigallocatechol

Sunphenon EGC

(-)-Epigallo catechin

(-)-Epigallocatechin

(−)-Epigallocatechin

(-)-Epigallocatechin (EGC)

(2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,5,7-chromanetriol

Teacatechin II

EPIGALLOCATECHIN

(2R,3R)-2-(3,4,5-Trihydroxyphenyl)chromane-3,5,7-triol

Greenteacatechins

(-)-EGC:2H-1-Benzopyran-3,5,7-triol,3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-, (2R-cis)-,

2H-1-Benzopyran-3,5,7-triol, 3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-, (2R,3R)-

epi

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