CAS 77182-82-2|Glufosinate ammonium

Introduction：Basic information about CAS 77182-82-2|Glufosinate ammonium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Glufosinate ammonium BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles13
8. Synonyms

Common Name	Glufosinate ammonium
CAS Number	77182-82-2	Molecular Weight	215.18800
Density	/	Boiling Point	519.1ºC at 760 mmHg
Molecular Formula	C₅H₁₅N₂O₄P	Melting Point	210°C
MSDS	ChineseUSA	Flash Point	100 °C
Symbol	GHS07, GHS08	Signal Word	Danger

Names

Name	glufosinate-ammonium
Synonym	More Synonyms

Glufosinate ammonium BiologicalActivity

Description	Glufosinate ammonium, a phosphinic acid analogue of glutamic acid, is an herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate ammonium exerts neurotoxic activity[1][2].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
In Vitro	Glufosinate ammonium (1-100 μM; 12DIV) disrupts cell-cell adhesion in differentiated V-SVZ neural stem cells (NSCs)[2]. Glufosinate ammonium (1-100 μM; 12DIV) significantly decreases Celsr2 gene expression at 100 μM[2]. Glufosinate ammonium impairs ependymal cell capability to synthetize cilia[2]. RT-PCR[2] Cell Line: Ependymal cells Concentration: 1, 3, 10, 100 μM Incubation Time: During 12DIV (NSCs-to-ependymal cells time point) Result: Significantly decreased Celsr2 gene expression at 100 μM.
In Vivo	Glufosinate ammonium (10-250 mg/kg; gavage; Daily; on days 6-15 of gestation) indicates maternal toxicity in the groups given 50 or 250 mg/kg in Wistar rats[3]. The Elimination of Glufosinate ammonium (oral intubation) in the blood takes place with a half-life of less than 4 hours in male and female rats[3].
References	[1]. Áy Z, et al. The effect of high concentrations of glufosinate ammonium on the yield components of transgenic spring wheat (Triticum aestivum L.) constitutively expressing the bar gene. ScientificWorldJournal. 2012;2012:657945. [2]. Feat-Vetel J, et al. Multiple effects of the herbicide glufosinate-ammonium and its main metabolite on neural stem cells from the subventricular zone of newborn mice. Neurotoxicology. 2018 Dec;69:152-163. [3]. Ebert E, et al. Summary of safety evaluation toxicity studies of glufosinate ammonium. Food Chem Toxicol. 1990 May;28(5):339-49.

Chemical & Physical Properties

Boiling Point	519.1ºC at 760 mmHg
Melting Point	210°C
Molecular Formula	C₅H₁₅N₂O₄P
Molecular Weight	215.18800
Flash Point	100 °C
Exact Mass	215.10300
PSA	116.09000
LogP	0.24480
InChIKey	ZBMRKNMTMPPMMK-UHFFFAOYSA-N
SMILES	CP(=O)(O)CCC(N)C(=O)O.N
Stability	Stable. Incompatible with strong oxidizing agents.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EK7713600

CHEMICAL NAME :: Butanoic acid, 2-amino-4-(hydroxymethylphosphinyl)-, monoammonium salt

CAS REGISTRY NUMBER :: 77182-82-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C5-H11-N-O4-P.H4-N

MOLECULAR WEIGHT :: 198.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 1600 uL/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

REFERENCE :: JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 7,47,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 1850 mg/kg

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes

REFERENCE :: VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 36,17,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1620 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C154,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A810,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 83 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,339,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 61 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,339,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 416 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,458,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 82 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,339,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 88 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,339,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,458,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18200 mg/kg/13W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - changes in bladder weight

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,339,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13978 mg/kg/13W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - changes in potassium Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,339,1990

Safety Information

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302 + H312 + H332-H360Fd-H373
Precautionary Statements	P201-P260-P280-P301 + P312 + P330-P308 + P313
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22
Safety Phrases	53-45
RIDADR	2588
RTECS	EK7713600
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2931901917

Customs

HS Code	2931900090
Summary	2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

Articles13

A review of methods for the analysis of orphan and difficult pesticides: glyphosate, glufosinate, quaternary ammonium and phenoxy acid herbicides, and dithiocarbamate and phthalimide fungicides.

J. AOAC Int. 97(4) , 965-77, (2014)

This article reviews the chromatography/MS methodologies for analysis of pesticide residues of orphan and difficult chemical classes in a variety of sample matrixes including water, urine, blood, and ...

Repression of flowering under a noninductive photoperiod by the HDA9-AGL19-FT module in Arabidopsis.

New Phytol. 206(1) , 281-94, (2015)

Posttranslational acetylation of histones is reversibly regulated by histone deacetylases (HDACs). Despite the evident significance of HDACs in Arabidopsis development, the biological roles and underl...

Role of glutamate receptors and nitric oxide on the effects of glufosinate ammonium, an organophosphate pesticide, on in vivo dopamine release in rat striatum.

Toxicology 311(3) , 154-61, (2013)

The purpose of the present work was to assess the possible role of glutamatergic receptors and nitric oxide (NO) production on effects of glufosinate ammonium (GLA), an organophosphate pesticide struc...

Synonyms

Glufosinate Ammonium

2-Amino-4-(hydroxymethylphosphinyl)butyric acid ammonium salt

2-Amino-4-(hydroxymethylphosphinyl)butanoic acid, monoammonium salt

DL-Phosphinothricin, monoammonium salt

2-Amino-4-(hydroxymethylphosphinyl)butanoic acid monoammonium salt

2-Amino-4-[hydroxy(methyl)phosphoryl]butanoic acid ammoniate (1:1)

Glufosinate ammonium salt

Ammonium (3-amino-3-carboxypropyl)methylphosphinate

ammonium (2RS)-2-amino-4-(methylphosphinato)butyric acid

Monoammonium 2-amino-4-(hydroxymethylphosphinyl)butanoate

Ammonium 2-amino-4-(hydroxymethylphosphinyl)butyrate

Basta

Monoammonium 4-[hydroxy(methyl)phosphinoyl]-DL-homoalaninate

2-Amino-4-[hydroxy(methyl)phosphoryl]butanoic acid ammoniate

QVYZ2PQO&1 &&(DL) Form NH4 Salt

Ammonium (DL-homoalanine-4-yl)methylphosphinate

Glufosinate-ammonium

MFCD00055562

Butanoic acid, 2-amino-4-(hydroxymethylphosphinyl)-, ammonium salt

Ammonium 2-amino-4-[hydroxy(methyl)phosphoryl]butanoate

glufosinate-ammonum

EINECS 278-636-5

Recommended......