Introduction：Basic information about CAS 74392-49-7|H-D-Phe-Phe-Arg-chloromethylketone trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | H-D-Phe-Phe-Arg-chloromethylketone trifluoroacetate salt |
|---|
| CAS Number | 74392-49-7 | Molecular Weight | 501.02100 |
|---|
| Density | 1.308g/cm3 | Boiling Point | / |
|---|
| Molecular Formula | C25H33ClN6O3 | Melting Point | / |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | H-D-Phe-Phe-Arg-chloromethylketone |
|---|
| Synonym | More Synonyms |
|---|
BiologicalActivity
| Description | PPACK II is an irreversible and specific glandular and plasma kallikreins inhibitor[1]. |
|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Ser/Thr ProteaseResearch Areas >>Cardiovascular Disease |
|---|
| In Vitro | PPACK II (0.62-50 μg/mL) 显着抑制 B 型钠尿肽 (BNP) 蛋白水解[2]。 |
|---|
| References | [1]. Kentaro Takayama, et al. Identification of a degrading enzyme in human serum that hydrolyzes a C-terminal core sequence of neuromedin U. Biopolymers. 2016 Nov 4;106(4):440-5. [2]. Alexander Belenky, et al. The effect of class-specific protease inhibitors on the stabilization of B-type natriuretic peptide in human plasma. Clin Chim Acta. 2004 Feb;340(1-2):163-72. |
|---|
Chemical & Physical Properties
| Density | 1.308g/cm3 |
|---|
| Molecular Formula | C25H33ClN6O3 |
|---|
| Molecular Weight | 501.02100 |
|---|
| Exact Mass | 500.23000 |
|---|
| PSA | 163.19000 |
|---|
| LogP | 3.51290 |
|---|
| Index of Refraction | 1.621 |
|---|
Synonyms
| phenylalanyl-phenylalanyl-argininechloromethylketone |
| D-Phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-L-phenylalaninamide |
| H-D-PHE-PHE-ARG-CMK TFA |
| DPHE-PHE-ARG-CHLOROMETHYLKETONE |
| D-Phe-Phe-Arg Chloromethylketone Trifluoroacetate Salt |
| H-D-PHE-PHE-ARG-CHLOROMETHYLKETONE TRIFLUOROACETATE SALT |
| DPHE-PHE-ARG-CMK |
| PPACK II,TRIFLUOROACETATE SALT |
