Introduction：Basic information about CAS 88546-74-1|H-D-Pro-Phe-Arg-chloromethylketone trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | H-D-Pro-Phe-Arg-chloromethylketone trifluoroacetate salt |
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| CAS Number | 88546-74-1 | Molecular Weight | 450.96200 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C21H31ClN6O3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | (2R)-N-[(2S)-1-[[(3S)-1-chloro-6-(diaminomethylideneamino)-2-oxohexan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | D-Pro-Phe-Arg-Chloromethylketone, a inhibitor of coagulation factor XII and plasma kallikrein, plays an important role in thrombosis and inflammation[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseResearch Areas >>Neurological DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Factor Xa |
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| References | [1]. Katrin F Nickel, et al. Factor XII as a Therapeutic Target in Thromboembolic and Inflammatory Diseases. Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):13-20. |
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Chemical & Physical Properties
| Molecular Formula | C21H31ClN6O3 |
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| Molecular Weight | 450.96200 |
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| Exact Mass | 450.21500 |
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| PSA | 149.20000 |
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| LogP | 2.32340 |
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| InChIKey | HCCRRLVJBLDSLL-BBWFWOEESA-N |
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| SMILES | NC(N)=NCCCC(NC(=O)C(Cc1ccccc1)NC(=O)C1CCCN1)C(=O)CCl |
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Synonyms
| D-Pro-Phe-Arg chloromethyl ketone |
| D-Pro-Phe-Arg chloromethyl ketone (PCK) |
| L-Phenylalaninamide,D-prolyl-N-[4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-,(S) |
| H-D-Pro-Phe-Arg-chloromethylketone |
