Introduction：Basic information about CAS 79994-24-4|Dynorphin A (1-10) acetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dynorphin A (1-10) acetate salt |
|---|
| CAS Number | 79994-24-4 | Molecular Weight | 1234.45000 |
|---|
| Density | / | Boiling Point | / |
|---|
| Molecular Formula | C57H91N19O12 | Melting Point | / |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | Dynorphin A (1-10), porcine,YGGFLRRIRP |
|---|
| Synonym | More Synonyms |
|---|
Dynorphin A (1-10) acetate salt BiologicalActivity
| Description | Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM. |
|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>iGluRSignaling Pathways >>Neuronal Signaling >>iGluRSignaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorPeptidesResearch Areas >>Neurological Disease |
|---|
| Target | κ-opioid receptor[1] NMDA receptor[2] |
|---|
| In Vitro | Dynorphin A (1-10) binds in the transmembrane domain of the κ-receptor[1]. The non-opioid actions of various forms of Dynorphin A (DynA) are examined on N-methyl-D-aspartate (NMDA) receptor channels in isolated rat trigeminal neurons using the whole-cell patch recording technique. All the dynorphins tested blocked NMDA-activated currents. The blocking actions are voltage-independent. The IC50 is 42.0 μM for DynA(1-10). To determine if shorter dynorphins have the similar blocking property, we examined the action of DynA(1-10) at different membrane potentials. DynA(1-10) blocks INMDA to a similar extent as the membrane potentials changed from -80 to +60 mV. Thus, despite a 160-fold difference in the apparent affinities, DynA(1-32) and DynA(1-10) both exert voltage-independent actions on NMDA receptors[2]. |
|---|
| References | [1]. Paterlini G, et al. Molecular simulation of dynorphin A-(1-10) binding to extracellular loop 2 of the kappa-opioidreceptor. A model for receptor activation. J Med Chem. 1997 Sep 26;40(20):3254-62. [2]. Chen L, et al. Dynorphin block of N-methyl-D-aspartate channels increases with the peptide length. J Pharmacol Exp Ther. 1998 Mar;284(3):826-31. |
|---|
Chemical & Physical Properties
| Molecular Formula | C57H91N19O12 |
|---|
| Molecular Weight | 1234.45000 |
|---|
| Exact Mass | 1233.71000 |
|---|
| PSA | 522.36000 |
|---|
| LogP | 3.94170 |
|---|
| InChIKey | XPAZYWMYTUESNI-UHFFFAOYSA-N |
|---|
| SMILES | CCC(C)C(NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)O |
|---|
| Storage condition | 2-8℃ |
|---|
Synonyms
| YGGFLRRIRP |
| dynorphin A fragment 1-10 porcine*sequence |
| DYNORPHIN A (1-10),PORCINE |
| DYNORPHIN A (1-10) |
| dynorphin A,porcine,fragment 1-10 |
| OPIOID AGONIST |
| H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH |
| TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO |
