Introduction：Basic information about CAS 33755-53-2|(+)-Biotin-ONP, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (+)-Biotin-ONP |
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| CAS Number | 33755-53-2 | Molecular Weight | 365.404 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 642.9±50.0 °C at 760 mmHg |
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| Molecular Formula | C16H19N3O5S | Melting Point | 163-165ºC |
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| MSDS | / | Flash Point | 342.6±30.1 °C |
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Names
| Name | (4-nitrophenyl) 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate |
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| Synonym | More Synonyms |
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(+)-Biotin-ONP BiologicalActivity
| Description | (+)-Biotin-ONP is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Alkyl-Chain |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 642.9±50.0 °C at 760 mmHg |
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| Melting Point | 163-165ºC |
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| Molecular Formula | C16H19N3O5S |
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| Molecular Weight | 365.404 |
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| Flash Point | 342.6±30.1 °C |
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| Exact Mass | 365.104553 |
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| PSA | 138.55000 |
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| LogP | 1.89 |
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| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
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| Index of Refraction | 1.584 |
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| InChIKey | YUDNXDTXQPYKCA-YDHLFZDLSA-N |
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| SMILES | O=C1NC2CSC(CCCCC(=O)Oc3ccc([N+](=O)[O-])cc3)C2N1 |
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Safety Information
Synonyms
| 1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, 4-nitrophenyl ester, (3aS,4S,6aR)- |
| Biotin-p-nitrophenyl ester |
| D-biotin 4-nitrophenyl ester |
| MFCD00005540 |
| D-Biotin P-Nitrophenyl Ester |
| (+)-Biotin 4-nitrophenyl ester |
| Biotinyl-4-nitrophenyl ester |
| D-(+)-biotin 2-nitrophenyl ester |
| 4-Nitrophenyl 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate |
| BNP,D-Biotin 4-nitrophenyl ester |
| 4-Nitrophenyl (+)-biotinate |
