CAS 643-12-9|D-(+)-CHIRO-INOSITOL

Introduction：Basic information about CAS 643-12-9|D-(+)-CHIRO-INOSITOL, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. D-(+)-CHIRO-INOSITOL BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	D-(+)-CHIRO-INOSITOL
CAS Number	643-12-9	Molecular Weight	180.156
Density	2.0±0.1 g/cm3	Boiling Point	291.3±40.0 °C at 760 mmHg
Molecular Formula	C₆H₁₂O₆	Melting Point	230 °C
MSDS	/	Flash Point	143.4±21.9 °C

Names

Name	d-(+)-chiro-inositol
Synonym	More Synonyms

D-(+)-CHIRO-INOSITOL BiologicalActivity

Description	D-chiro-Inositol is an epimer of myo-inositol found in certain mammalian glycosylphosphatidylinositol protein anchors and inositol phosphoglycans possessing insulin-like bioactivity. D-chiro-Inositol is used clinically for the treatment of polycystic ovary syndrome (PCOS) and diabetes mellitus, which can reduce hyperglycemia and ameliorate insulin resistance[1][2][3].
Related Catalog	Research Areas >>Metabolic Disease
References	[1]. Ostlund RE Jr, et al. A stereospecific myo-inositol/D-chiro-inositol transporter in HepG2 liver cells. Identification with D-chiro-[3-3H]inositol. J Biol Chem. 1996 Apr 26;271(17):10073-8. [2]. Zhao SS, et al. D-chiro-inositol effectively attenuates cholestasis in bile duct ligated rats by improving bile acidsecretion and attenuating oxidative stress. Acta Pharmacol Sin. 2018 Feb;39(2):213-221. [3]. Cheng F, et al. chiro-Inositol Ameliorates High Fat Diet-Induced Hepatic Steatosis and Insulin Resistance viaPKCε-PI3K/AKT Pathway. J Agric Food Chem. 2019 May 29;67(21):5957-5967.

Description

D-chiro-Inositol is an epimer of myo-inositol found in certain mammalian glycosylphosphatidylinositol protein anchors and inositol phosphoglycans possessing insulin-like bioactivity. D-chiro-Inositol is used clinically for the treatment of polycystic ovary syndrome (PCOS) and diabetes mellitus, which can reduce hyperglycemia and ameliorate insulin resistance[1][2][3].

Related Catalog

Research Areas >>Metabolic Disease

References

[1]. Ostlund RE Jr, et al. A stereospecific myo-inositol/D-chiro-inositol transporter in HepG2 liver cells. Identification with D-chiro-[3-3H]inositol. J Biol Chem. 1996 Apr 26;271(17):10073-8.

[2]. Zhao SS, et al. D-chiro-inositol effectively attenuates cholestasis in bile duct ligated rats by improving bile acidsecretion and attenuating oxidative stress. Acta Pharmacol Sin. 2018 Feb;39(2):213-221.

[3]. Cheng F, et al. chiro-Inositol Ameliorates High Fat Diet-Induced Hepatic Steatosis and Insulin Resistance viaPKCε-PI3K/AKT Pathway. J Agric Food Chem. 2019 May 29;67(21):5957-5967.

Chemical & Physical Properties

Density	2.0±0.1 g/cm3
Boiling Point	291.3±40.0 °C at 760 mmHg
Melting Point	230 °C
Molecular Formula	C₆H₁₂O₆
Molecular Weight	180.156
Flash Point	143.4±21.9 °C
Exact Mass	180.063385
PSA	121.38000
LogP	-2.11
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.784
Storage condition	Freezer

Safety Information

Hazard Codes	Xn
Risk Phrases	R20/21/22
Safety Phrases	S24/25
HS Code	29061390

Customs

HS Code	29061390

Synonyms

cyclohexanehexol

D-Inositol

(1R,2R,3S,4S,5S,6S)-1,2,3,4,5,6-Cyclohexanehexol

1,2,3,4,5,6-Cyclohexanehexol, (1α,2α,3β,4α,5β,6β)-

(1R,2R,3S,4S,5S,6S)-Cyclohexane-1,2,3,4,5,6-hexol

(1R,2R,3S,4S,5S,6S)-Cyclohexan-1,2,3,4,5,6-hexol

1,2,4/3,5,6-hexahydroxycyclohexane

1D-chiro-Inositol

(+)-1,2,4/3,5,6-Inositol

cis-inositol

EINECS 211-394-0

D-Chiro-inositol(DCI)

D-CHIRO-INOSITOL(DISD)

MFCD00272608

D-(+)-Inositol

D-chiro-inositol

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