Introduction：Basic information about CAS 58994-96-0|ranimustine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ranimustine |
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| CAS Number | 58994-96-0 | Molecular Weight | 327.71900 |
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| Density | 1.69 g/cm3 | Boiling Point | / |
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| Molecular Formula | C10H18ClN3O7 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Ranimustine |
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| Synonym | More Synonyms |
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ranimustine BiologicalActivity
| Description | Ranimustine (MCNU) is a nitrosourea alkylating agent, can be used for research of chronic myelogenous leukemia and polycythemia vera[1][3][4]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>DNA Alkylator/Crosslinker |
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| In Vivo | Ranimustine reduces spermidine and spermine in the corpus striatum, and spermine in the diencephalon, but increases putrescine in the corpus striatum and combined thalamus and hypothalamus[2]. |
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Chemical & Physical Properties
| Density | 1.69 g/cm3 |
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| Molecular Formula | C10H18ClN3O7 |
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| Molecular Weight | 327.71900 |
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| Exact Mass | 327.08300 |
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| PSA | 140.92000 |
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| Index of Refraction | 1.616 |
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| InChIKey | AHHFEZNOXOZZQA-ZEBDFXRSSA-N |
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| SMILES | COC1OC(CNC(=O)N(CCCl)N=O)C(O)C(O)C1O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- LZ5910000
- CHEMICAL NAME :
- Glucopyranoside, methyl-6-((((2-chloroethyl)nitrosoamino)carbonyl)amin o)-6-deoxy-, alpha-D-
- CAS REGISTRY NUMBER :
- 58994-96-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C10-H18-Cl-N3-O7
- MOLECULAR WEIGHT :
- 327.76
- WISWESSER LINE NOTATION :
- T6OTJ BO1 CQ DQ EQ F1MVNNO&2G
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 46400 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 37 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 31800 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 45700 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 39 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 41200 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 5 mg/kg
- SEX/DURATION :
- female 5 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
MUTATION DATA - TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - mouse Leukocyte
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- AMKUDT Acta Medica Kinki University. (Kinki Univ. Medical Assoc., 380 Nishiyama, Sayama-cho, Minami-kawachi-gun, Osaka-fu, Japan) V.1- 1976- Volume(issue)/page/year: 11,57,1986
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Safety Information
| Hazard Codes | T |
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| Risk Phrases | R25:Toxic if swallowed. R41:Risk of serious damage to eyes. R43:May cause sensitization by skin contact. |
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| Safety Phrases | S26-S36/37/39-S45 |
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| RIDADR | UN 2811 6.1/PG 3 |
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| WGK Germany | 3 |
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| RTECS | XU7700000 |
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| Packaging Group | III |
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| Hazard Class | 6.1 |
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Synonyms
| Cymerin |
| MCNU |
| MFCD00866369 |
| Thymerin |
| RCL L16,919-6 |
| 1-(2-chloroethyl)-1-nitroso-3-[[(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-methoxy-oxan-2-yl]methyl]urea |
| Ranomustine |
