CAS 1878-66-6|4-Chlorophenylacetic acid
| Common Name | 4-Chlorophenylacetic acid | ||
|---|---|---|---|
| CAS Number | 1878-66-6 | Molecular Weight | 170.593 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 294.1±15.0 °C at 760 mmHg |
| Molecular Formula | C8H7ClO2 | Melting Point | 102-105 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 131.7±20.4 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 4-chlorophenylacetic acid |
|---|---|
| Synonym | More Synonyms |
4-Chlorophenylacetic acid BiologicalActivity
| Description | 4-Chlorophenylacetic acid is a compound belongs to a family of small aromatic fatty acids with anticancer properties. 4-Chlorophenylacetic acid can provide carbon and energy for Pseudomonas sp[1][2]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
| References | [1]. U Klages, et al. Degradation of 4-chlorophenylacetic Acid by a Pseudomonas Species. J Bacteriol. 1981 Apr;146(1):64-8. [2]. Neil Sidell, et al. Inhibition of Estrogen-Induced Mammary Tumor Formation in MMTV-aromatase Transgenic Mice by 4-chlorophenylacetate. Cancer Lett. 2007 Jun 28;251(2):302-10. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 294.1±15.0 °C at 760 mmHg |
| Melting Point | 102-105 °C(lit.) |
| Molecular Formula | C8H7ClO2 |
| Molecular Weight | 170.593 |
| Flash Point | 131.7±20.4 °C |
| Exact Mass | 170.013458 |
| PSA | 37.30000 |
| LogP | 2.10 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.570 |
| InChIKey | CDPKJZJVTHSESZ-UHFFFAOYSA-N |
| SMILES | O=C(O)Cc1ccc(Cl)cc1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1350 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 13,286,1958
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H312 + H332 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful;Xi: Irritant; |
| Risk Phrases | R20/21 |
| Safety Phrases | S36/37-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | AG0590000 |
| HS Code | 2916340090 |
Customs
| HS Code | 2916399090 |
|---|---|
| Summary | 2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
Articles9
More Articles| Novel Chryseobacterium sp. PYR2 degrades various organochlorine pesticides (OCPs) and achieves enhancing removal and complete degradation of DDT in highly contaminated soil. J. Environ. Manage. 161 , 350-7, (2015) Long term residues of organochlorine pesticides (OCPs) in soils are of great concerning because they seriously threaten food security and human health. This article focuses on isolation of OCP-degradi... | |
| Degradation of 4-chlorophenylacetic acid by a Pseudomonas species. J. Bacteriol. 146(1) , 64-8, (1981) Pseudomonas sp. strain CBS3 was able to utilize 4-chlorophenylacetic acid as the sole source of carbon and energy. When this strain was grown with 4-chlorophenylacetic acid, homoprotocatechuic acid wa... | |
| Inhibition of estrogen-induced mammary tumor formation in MMTV-aromatase transgenic mice by 4-chlorophenylacetate. Cancer Lett. 251(2) , 302-10, (2007) Treatment of estrogen-sensitive breast cancer with selective estrogen selective modulators (SERMs) and, more recently, aromatase inhibitors has met with wide success. However, antagonism of estrogen r... |
Synonyms
| EINECS 217-521-6 |
| Acetic acid, 4-chlorophenyl- |
| (4-Chlorophenyl)acetic acid |
| 4-Chlorobenzeneacetic acid |
| 4-Chlorophenylacetic acid |
| 2-(4-chloro-phenyl)-acetic acid |
| p-chlorophenylacetate |
| Acetic acid,(p-chlorophenyl) |
| 4-Cl-phenylacetic acid |
| p-chlorophenyl acetic acid |
| Benzeneacetic acid,4-chloro |
| Benzeneacetic acid, 4-chloro- |
| 2-(4-chlorophenyl)acetic acid |
| P-CHLOROPHENYLACETIC ACID |
| 2-(p-Chlorophenyl)acetic acid |
| 4-ClPhCH2CO2H |
| Acetic acid, (p-chlorophenyl)- |
| MFCD00004344 |
