CAS 7786-61-0|4-Hydroxy-3-methoxystyrene

Introduction：Basic information about CAS 7786-61-0|4-Hydroxy-3-methoxystyrene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 4-Hydroxy-3-methoxystyrene BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Articles27
8. Synonyms

Common Name	4-Hydroxy-3-methoxystyrene
CAS Number	7786-61-0	Molecular Weight	150.174
Density	1.1±0.1 g/cm3	Boiling Point	245.0±20.0 °C at 760 mmHg
Molecular Formula	C₉H₁₀O₂	Melting Point	25-29°C
MSDS	ChineseUSA	Flash Point	111.3±6.7 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	2-methoxy-4-vinylphenol
Synonym	More Synonyms

4-Hydroxy-3-methoxystyrene BiologicalActivity

Description	2-Methoxy-4-vinylphenol (2M4VP), a naturally Germination inhibitor, exerts potent anti-inflammatory effects[1][2].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology
In Vitro	2-Methoxy-4-vinylphenol (2M4VP) potently inhibits the translocation of NF-κB p65 into the nucleus by IκB degradation following IκB-α phosphorylation and the phosphorylation of MAPKs such as p38, ERK1/2, and JNK[1]. 2-Methoxy-4-vinylphenol (2M4VP) inhibits hyper-acetylation of histone H3 (Lys9/Lys14) induced by LPS[1]. Western Blot Analysis[1] Cell Line: RAW264.7 cells. Concentration: 0-40 μM. Incubation Time: 24 h. Result: Inhibited the over-expression of iNOS and COX-2 protein in LPS-stimulated RAW264.7 cells.
References	[1]. Jin Boo Jeong, et al. Anti-inflammatory Effect of 2-methoxy-4-vinylphenol via the Suppression of NF-κB and MAPK Activation, and Acetylation of Histone H3. Arch Pharm Res. 2011 Dec;34(12):2109-16. [2]. Hossein Reza Darabi, et al. A Structure-Activity Relationship Study on a Natural Germination Inhibitor, 2-methoxy-4-vinylphenol (MVP), in Wheat Seeds to Evaluate Its Mode of Action. Z Naturforsch C J Biosci. Sep-Oct 2007;62(9-10):694-700.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	245.0±20.0 °C at 760 mmHg
Melting Point	25-29°C
Molecular Formula	C₉H₁₀O₂
Molecular Weight	150.174
Flash Point	111.3±6.7 °C
Exact Mass	150.068085
PSA	29.46000
LogP	1.93
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.578
InChIKey	YOMSJEATGXXYPX-UHFFFAOYSA-N
SMILES	C=Cc1ccc(O)c(OC)c1
Storage condition	2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL8205000

CHEMICAL NAME :: Phenol, 2-methoxy-4-vinyl-

CAS REGISTRY NUMBER :: 7786-61-0

BEILSTEIN REFERENCE NO. :: 2044521

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H10-O2

MOLECULAR WEIGHT :: 150.19

WISWESSER LINE NOTATION :: 1U1R DQ CO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1400 mg/kg

SEX/DURATION :: female 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - other measures of fertility

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 500 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 206,17,1988

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	SL8205000
HS Code	2909500000

Customs

HS Code	2909500000
Summary	2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles27

Purification and characterization of the Staphylococcus aureus bacillithiol transferase BstA.

Biochim. Biophys. Acta 1840(9) , 2851-61, (2014)

Gram-positive bacteria in the phylum Firmicutes synthesize the low molecular weight thiol bacillithiol rather than glutathione or mycothiol. The bacillithiol transferase YfiT from Bacillus subtilis wa...

Approaches of aroma extraction dilution analysis (AEDA) for headspace solid phase microextraction and gas chromatography-olfactometry (HS-SPME-GC-O): Altering sample amount, diluting the sample or adjusting split ratio?

Food Chem. 187 , 44-52, (2015)

Aroma extract dilution analysis (AEDA) is widely used for the screening of aroma-active compounds in gas chromatography-olfactometry (GC-O). In this study, three aroma dilution methods, (I) using diff...

Bioprocess design for the microbial production of natural phenolic compounds by Debaryomyces hansenii.

Appl. Biochem. Biotechnol. 168(8) , 2268-84, (2012)

Debaryomyces hansenii NRRL Y-7426 metabolised ferulic acid into different phenolic compounds using a factorial design where glucose concentration (in the range of 1-20 g/L), peptone concentration (2-2...

Synonyms

p-Vinyl guaiacol

p-vinylguaiacol

MFCD00015437

3-06-00-04981 (Beilstein Handbook Reference)

o-Methoxy-p-vinylphenol

2-Methoxy-4-vinylphenol

Phenol, 2-methoxy-4-vinyl-

Phenol, 4-ethenyl-2-methoxy-

4-Hydroxy-3-methoxystyrene

2-Methoxy-4-ethenylphenol

EINECS 232-101-2

2-METHOXY-4-VINYL-PHENOL

3-Methoxy-4-hydroxystyrene

4-ETHENYL-2-METHOXYPHENOL

4-VINYLGUAIACOL

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