CAS 78957-85-4|A-3 hydrochloride
Introduction：Basic information about CAS 78957-85-4|A-3 hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | A-3 hydrochloride | ||
|---|---|---|---|
| CAS Number | 78957-85-4 | Molecular Weight | 321.22300 |
| Density | / | Boiling Point | / |
| Molecular Formula | C12H14Cl2N2O2S | Melting Point | 173-176ºC |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | N-(2-Aminoethyl)-5-chloro-1-naphthalenesulfonamide, Hydrochloride |
|---|---|
| Synonym | More Synonyms |
A-3 hydrochloride BiologicalActivity
| Description | A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectively[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Epigenetics >>PKCSignaling Pathways >>Neuronal Signaling >>CaMKSignaling Pathways >>Protein Tyrosine Kinase/RTK >>PKAResearch Areas >>OthersSignaling Pathways >>Stem Cell/Wnt >>PKASignaling Pathways >>Cell Cycle/DNA Damage >>Casein KinaseSignaling Pathways >>Stem Cell/Wnt >>Casein KinaseSignaling Pathways >>TGF-beta/Smad >>PKC |
| Target | CK1:80 μM (Ki) CK2:5.1 μM (Ki) PKC:47 μM (Ki) PKA:4.3 μM (Ki) |
| In Vitro | A-3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that the Ki value is 7.4 μM. A-3 is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively[1]. |
| References | [1]. Inagaki M, et al. Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors. Mol Pharmacol. 1986 Jun;29(6):577-81. |
Chemical & Physical Properties
| Melting Point | 173-176ºC |
|---|---|
| Molecular Formula | C12H14Cl2N2O2S |
| Molecular Weight | 321.22300 |
| Exact Mass | 320.01500 |
| PSA | 80.57000 |
| LogP | 4.70420 |
| InChIKey | VWAGIWCLJAQLAL-UHFFFAOYSA-N |
| SMILES | Cl.NCCNS(=O)(=O)c1cccc2c(Cl)cccc12 |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
Synonyms
| a-3 hydrochloride |
