CAS 108068-98-0|KT5720
| Common Name | KT5720 | ||
|---|---|---|---|
| CAS Number | 108068-98-0 | Molecular Weight | 537.60600 |
| Density | 1.49g/cm3 | Boiling Point | 715ºC at 760mmHg |
| Molecular Formula | C32H31N3O5 | Melting Point | / |
| MSDS | USA | Flash Point | 386.2ºC |
Names
| Name | kt 5720 |
|---|---|
| Synonym | More Synonyms |
KT5720 BiologicalActivity
| Description | KT5720 is a cell-permeable, potent, specific, reversible, ATP-competitive inhibitor of protein kinase A (PKA), with a Ki of 60 nM[1][2]. |
|---|---|
| Related Catalog | Research Areas >>EndocrinologySignaling Pathways >>Protein Tyrosine Kinase/RTK >>PKASignaling Pathways >>Stem Cell/Wnt >>PKAResearch Areas >>Metabolic Disease |
| Target | Ki: 60 nM (PKA)[1][2]. |
| References | [1]. Davies SP, et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. [2]. Murray A, et al. Pharmacological PKA inhibition: all may not be what it seems. Sci Signal. 2008 Jun 3;1(22):re4. |
Chemical & Physical Properties
| Density | 1.49g/cm3 |
|---|---|
| Boiling Point | 715ºC at 760mmHg |
| Molecular Formula | C32H31N3O5 |
| Molecular Weight | 537.60600 |
| Flash Point | 386.2ºC |
| Exact Mass | 537.22600 |
| PSA | 94.72000 |
| LogP | 5.93440 |
| Vapour Pressure | 1.88E-21mmHg at 25°C |
| Index of Refraction | 1.752 |
| InChIKey | ZHEHVZXPFVXKEY-RUAOOFDTSA-N |
| SMILES | CCCCCCOC(=O)C1(O)CC2OC1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 |
Safety Information
| Hazard Codes | Xi |
|---|---|
| Risk Phrases | R36/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
Articles30
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| Involvement of cAMP in nerve growth factor-triggered p35/Cdk5 activation and differentiation in PC12 cells. Am. J. Physiol. Cell Physiol. 299 , C516-27, (2010) The signaling mechanisms underlying cell differentiation have been extensively studied with the use of rat PC12 cells as a model system. Nerve growth factor (NGF) is a trophic factor inducing PC12 cel... | |
| Prostaglandin potentiates 5-HT responses in stomach and ileum innervating visceral afferent sensory neurons. Biochem. Biophys. Res. Commun. 456(1) , 167-72, (2015) Gastrointestinal disorder is a common symptom induced by diverse pathophysiological conditions that include food tolerance, chemotherapy, and irradiation for therapy. Prostaglandin E2 (PGE2) level inc... |
Synonyms
| MFCD00132118 |
