CAS 181629-93-6|SB 228357
Introduction：Basic information about CAS 181629-93-6|SB 228357, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | SB 228357 | ||
|---|---|---|---|
| CAS Number | 181629-93-6 | Molecular Weight | 431.38300 |
| Density | 1.398g/cm3 | Boiling Point | 625.4ºC at 760mmHg |
| Molecular Formula | C22H17F4N3O2 | Melting Point | / |
| MSDS | / | Flash Point | 332ºC |
Names
| Name | N-(3-fluoro-5-pyridin-3-ylphenyl)-5-methoxy-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide |
|---|---|
| Synonym | More Synonyms |
SB 228357 BiologicalActivity
| Description | SB228357 is a selective, potent oral active 5-HT2C/2B receptor antagonist with pKi values of 6.9, 8.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. SB228357 has antidepressant/anxiolytic effects[1][2]. |
|---|---|
| Target | 5-HT2A Receptor:6.9 (pKi) 5-HT2C Receptor:9 (pKi) 5-HT2B Receptor:8 (pKi) |
| In Vivo | SB228357 (0-10 mg/kg; oral administration; for 90 minutes; male Sprague Dawley rats) treatment significantly reverses Haloperidol-induced catalepsy[2]. Animal Model: Male Sprague Dawley rats (200-250 g) injected with Haloperidol[2] Dosage: 0 mg/kg, 0.32 mg/kg, 1 mg/kg, 3.2 mg/kg, 10 mg/kg Administration: Oral administration; for 90 minutes Result: Significantly reversed Haloperidol-induced catalepsy. |
| References | [1]. Bromidge SM, et al. Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent. J Med Chem. 2000 Mar 23;43(6):1123-34. [2]. Reavill C, et al. Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br J Pharmacol. 1999 Feb;126(3):572-4. |
Chemical & Physical Properties
| Density | 1.398g/cm3 |
|---|---|
| Boiling Point | 625.4ºC at 760mmHg |
| Molecular Formula | C22H17F4N3O2 |
| Molecular Weight | 431.38300 |
| Flash Point | 332ºC |
| Exact Mass | 431.12600 |
| PSA | 54.46000 |
| LogP | 5.64770 |
| Vapour Pressure | 1.48E-15mmHg at 25°C |
| Index of Refraction | 1.599 |
| InChIKey | RRJLJKRFFRZRAF-UHFFFAOYSA-N |
| SMILES | COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(F)cc(-c3cccnc3)c1)CC2 |
Safety Information
| Safety Phrases | 22-24/25 |
|---|---|
| WGK Germany | 3 |
Synonyms
| Tocris-1375 |
| Lopac-S-2318 |
