CAS 10045-45-1|1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one
| Common Name | 1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one | ||
|---|---|---|---|
| CAS Number | 10045-45-1 | Molecular Weight | 162.189 |
| Density | 1.161±0.06 g/cm3 | Boiling Point | / |
| Molecular Formula | C9H10N2O | Melting Point | 122 ºC |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 1-Ethyl-1H-benzo[d]imidazol-2(3H)-one |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | 1-EBIO is an activator of Ca2+ sensitive K+ channels. 1-EBIO is used to study the role of K+ channels in diverse physiological functions[1]. |
|---|---|
| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel |
| References | [1]. Devor DC, et al. Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a Ca(2+)-dependent K+ channel. Am J Physiol. 1996 Nov;271(5 Pt 1):L775-84. |
Chemical & Physical Properties
| Density | 1.161±0.06 g/cm3 |
|---|---|
| Melting Point | 122 ºC |
| Molecular Formula | C9H10N2O |
| Molecular Weight | 162.189 |
| Exact Mass | 162.079315 |
| PSA | 37.79000 |
| LogP | 1.39 |
| Appearance of Characters | powder |
| Index of Refraction | 1.566 |
| InChIKey | CXUCKELNYMZTRT-UHFFFAOYSA-N |
| SMILES | CCn1c(=O)[nH]c2ccccc21 |
| Storage condition | Store at RT |
| Water Solubility | Slightly soluble (1.6 g/L) (25 ºC) |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Phrases | 22-36 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles33
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| Type 2 diabetes: increased expression and contribution of IKCa channels to vasodilation in small mesenteric arteries of ZDF rats. Am. J. Physiol. Heart Circ. Physiol. 307(8) , H1093-102, (2014) Impaired endothelial function, which is dysregulated in diabetes, also precedes hypertension. We hypothesized that in Type 2 diabetes, the impaired endothelium-dependent relaxation is due to a loss of... | |
| Firing pattern modulation through SK channel current increase underlies neuronal survival in an organotypic slice model of Parkinson's disease. Mol. Neurobiol. 51(1) , 424-36, (2015) Dopaminergic (DA) neurons in substantia nigra pars compacta (SNc) are vulnerable to excitotoxicity in Parkinson's disease (PD). Neurotoxic stimuli may alter the firing patterns of DA neurons. However,... |
Synonyms
| 2H-Benzimidazol-2-one, 1-ethyl-1,3-dihydro- |
| EINECS 233-148-1 |
| 1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one |
