CAS 52497-36-6|Dihydrokainic acid
| Common Name | Dihydrokainic acid | ||
|---|---|---|---|
| CAS Number | 52497-36-6 | Molecular Weight | 215.25 |
| Density | 1.187g/cm3 | Boiling Point | 416.6ºC at 760mmHg |
| Molecular Formula | C10H17NO4 | Melting Point | 285 °C (dec.) |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | dihydrokainic acid |
|---|---|
| Synonym | More Synonyms |
Dihydrokainic acid BiologicalActivity
| Description | Dihydrokainic acid (DHK) is a glutamate transporter GLT1 (EAAT2) inhibitor. Dihydrokainic acid impairs novel object recognition (NOR) memory performance in mice. Dihydrokainic acid also shows epileptogenic effects[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>EAAT2Research Areas >>Neurological Disease |
| Target | GLT1[1] |
| References | [1]. Tian SW, et al. Glutamate transporter GLT1 inhibitor dihydrokainic acid impairs novel object recognition memory performance in mice. Physiol Behav. 2019 Feb 1;199:28-32. [2]. Butcher SP, et al. On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat. Neuropharmacology. 1988 Apr;27(4):375-81. |
Chemical & Physical Properties
| Density | 1.187g/cm3 |
|---|---|
| Boiling Point | 416.6ºC at 760mmHg |
| Melting Point | 285 °C (dec.) |
| Molecular Formula | C10H17NO4 |
| Molecular Weight | 215.25 |
| Exact Mass | 215.11600 |
| PSA | 86.63000 |
| LogP | 0.73470 |
| Index of Refraction | 1.492 |
| InChIKey | JQPDCKOQOOQUSC-OOZYFLPDSA-N |
| SMILES | CC(C)C1CNC(C(=O)O)C1CC(=O)O |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H332 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | 20/21/22 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles37
More Articles| EAAT2 (GLT-1; slc1a2) glutamate transporters reconstituted in liposomes argues against heteroexchange being substantially faster than net uptake. J. Neurosci. 34(40) , 13472-85, (2014) The EAAT2 glutamate transporter, accounts for >90% of hippocampal glutamate uptake. Although EAAT2 is predominantly expressed in astrocytes, ∼10% of EAAT2 molecules are found in axon terminals. Despit... | |
| Activation of sodium-dependent glutamate transporters regulates the morphological aspects of oligodendrocyte maturation via signaling through calcium/calmodulin-dependent kinase IIβ's actin-binding/-stabilizing domain. Glia 62(9) , 1543-58, (2014) Signaling via the major excitatory amino acid glutamate has been implicated in the regulation of various aspects of the biology of oligodendrocytes, the myelinating cells of the central nervous system... | |
| A functional coupling between extrasynaptic NMDA receptors and A-type K+ channels under astrocyte control regulates hypothalamic neurosecretory neuronal activity. J. Physiol. 592(Pt 13) , 2813-27, (2014) Neuronal activity is controlled by a fine-tuned balance between intrinsic properties and extrinsic synaptic inputs. Moreover, neighbouring astrocytes are now recognized to influence a wide spectrum of... |
Synonyms
| 2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid |
| MFCD03412037 |
| (2S,3S,4R)-3-(carboxymethyl)-4-propan-2-ylpyrrolidine-2-carboxylic acid |
| Dihydrokainic acid |
