CAS 32385-58-3|Imetit dihydrobromide
| Common Name | Imetit dihydrobromide | ||
|---|---|---|---|
| CAS Number | 32385-58-3 | Molecular Weight | 332.05900 |
| Density | / | Boiling Point | 430.8ºC at 760mmHg |
| Molecular Formula | C6H12Br2N4S | Melting Point | 206 - 207 °C |
| MSDS | ChineseUSA | Flash Point | 214.3ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | imetit dihydrobromide |
|---|---|
| Synonym | More Synonyms |
Imetit dihydrobromide BiologicalActivity
| Description | Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM)[1][2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Histamine Receptor |
| Target | H3 Receptor:0.3 nM (Ki) H4 receptor:2.7 nM (Ki) |
| In Vivo | Imetit dihydrobromide (2.5-10 mg/kg; i.p.) reduces the licking response induced by Apomorphine[4]. Animal Model: Male Sprague-Dawley rats[4] Dosage: 2.5, 5, 10 mg/kg Administration: i.p. (30 min before Apomorphine) Result: Reduced the licking response induced by Apomorphine. |
| References | [1]. Liu C, et al. Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6. [2]. Ling P, et al. Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br J Pharmacol. 2004 May;142(1):161-71. [3]. Garbarg M, et al. S-[2-(4-imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist. J Pharmacol Exp Ther. 1992 Oct;263(1):304-10. [4]. Farzin D, et al. Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rat. Eur J Pharmacol. 2000 Sep 15;404(1-2):169-74. |
Chemical & Physical Properties
| Boiling Point | 430.8ºC at 760mmHg |
|---|---|
| Melting Point | 206 - 207 °C |
| Molecular Formula | C6H12Br2N4S |
| Molecular Weight | 332.05900 |
| Flash Point | 214.3ºC |
| Exact Mass | 329.91500 |
| PSA | 103.85000 |
| LogP | 3.29510 |
| InChIKey | DOBOYMKCRRLTRF-UHFFFAOYSA-N |
| SMILES | Br.Br.N=C(N)SCCc1cnc[nH]1 |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933290090 |
Customs
| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles1
More Articles| S-[2-(4-imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist. J. Pharmacol. Exp. Ther. 263 , 304, (1992) The effects of a new agonist of histamine (HA) H3 receptors, Imetit (S-[2-(4-(imidazolyl)ethyl]isothiourea) were investigated in vitro and in vivo and compared to those of (R)-alpha-methylhistamine [(... |
Synonyms
| Imetit dihydrobromide |
| S-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide |
