Introduction：Basic information about CAS 178064-02-3|Nociceptin (1-13) amide trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Nociceptin (1-13) amide trifluoroacetate salt |
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| CAS Number | 178064-02-3 | Molecular Weight | 1381.59 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C61H100N22O15 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Nociceptin (1-13)NH2 |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes[1][2]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorResearch Areas >>Neurological Disease |
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| Target | Ki: 0.75 nM (binding to rat forebrain membranes)[1] pEC50: 7.9 (in mouse vas deferens)[2] |
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| References | [1]. Varani K, et al. Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships. Br J Pharmacol. 1998 Dec;125(7):1485-90. [2]. Calo' G, et al. Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br J Pharmacol. 2000 Apr;129(7):1261-83. |
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Chemical & Physical Properties
| Molecular Formula | C61H100N22O15 |
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| Molecular Weight | 1381.59 |
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| Exact Mass | 1380.77000 |
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| PSA | 634.61000 |
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| LogP | 1.06750 |
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| InChIKey | RHMALYOXPBRJBG-CGUXNFSNSA-N |
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| SMILES | CC(NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccccc1)C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCCN)C(N)=O |
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Synonyms
| phe-gly-gly-phe-thr-gly-ala-arg-lys-ser-ala-arg-lys-nh2 |
| h-phe-gly-gly-phe-thr-gly-ala-arg-lys-ser-ala-arg-lys-nh2 |
| phe-gly-gly-phe-thr-gly-ala-arg-lys-nh2 |
