Introduction：Basic information about CAS 167710-87-4|RS 39604 hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | RS 39604 hydrochloride |
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| CAS Number | 167710-87-4 | Molecular Weight | 590.55900 |
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| Density | / | Boiling Point | 746.9ºC at 760 mmHg |
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| Molecular Formula | C26H37Cl2N3O6S | Melting Point | / |
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| MSDS | / | Flash Point | 405.5ºC |
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Names
| Name | N-[2-[4-[3-[4-amino-5-chloro-2-[(3,5-dimethoxyphenyl)methoxy]phenyl]-3-oxopropyl]piperidin-1-yl]ethyl]methanesulfonamide,hydrochloride |
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| Synonym | More Synonyms |
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RS 39604 hydrochloride BiologicalActivity
| Description | RS 39604 is a potent, selective, and orally active 5-HT4 receptor antagonist with a pKi of 9.1 in guinea pig striatal membranes. RS 39604 displays a low affinity (pKi<6.5) for 5-HT1A, 5-HT2C, 5-HT3, α1c, D1, D2, M1, M2, AT1, B1 and opioid mu receptors and moderate affinity for δ1, (pKi=6.8) and δ2 (pKi=7.8) sites[1]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
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| Target | 5-HT4 Receptor:9.1 (pKi) |
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| References | [1]. Hegde SS, et al. RS 39604: a potent, selective and orally active 5-HT4 receptor antagonist. Br J Pharmacol. 1995;115(6):1087-1095. |
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Chemical & Physical Properties
| Boiling Point | 746.9ºC at 760 mmHg |
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| Molecular Formula | C26H37Cl2N3O6S |
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| Molecular Weight | 590.55900 |
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| Flash Point | 405.5ºC |
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| Exact Mass | 589.17800 |
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| PSA | 128.57000 |
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| LogP | 6.53530 |
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| Vapour Pressure | 1.25E-22mmHg at 25°C |
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| InChIKey | QSMYZGMJSGUWPM-UHFFFAOYSA-N |
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| SMILES | COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)cc(OC)c1.Cl |
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Synonyms
