CAS 63735-71-7|AEG 3482
Introduction：Basic information about CAS 63735-71-7|AEG 3482, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | AEG 3482 | ||
|---|---|---|---|
| CAS Number | 63735-71-7 | Molecular Weight | 280.326 |
| Density | 1.8±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C10H8N4O2S2 | Melting Point | / |
| MSDS | / | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 6-phenylimidazo[2,1-b][1,3,4]thiadiazole-2-sulfonamide |
|---|---|
| Synonym | More Synonyms |
AEG 3482 BiologicalActivity
| Description | AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Neurological DiseaseSignaling Pathways >>MAPK/ERK Pathway >>JNK |
| Target | JNK[1] |
| In Vitro | AEG3482 (0.3-30 μM; 2 d) inhibits nerve growth factor (NGF) withdrawal-induced death in SCG neurons, with an EC50 of ∼20 μM[1]. AEG3482 (1-80 μM; 40 h) inhibits p75NTR- and NRAGE- mediated apoptosis of PC12 cells in a dose-dependent manner[1]. AEG3482 (10-40 μM; 30 h) inhibits p75NTR- and NRAGE-mediated JNK activation in PC12 cells[1]. Apoptosis Analysis[1] Cell Line: PC12 cells Concentration: 1, 2.5, 5, 10, 20, 40, 80 μM Incubation Time: 40 hours Result: Reduced p75NTR- or NRAGE-induced cell death by greater than 90% at the concentration of 40 μM. Exerted a slight toxic effect in cells infected with the LacZ control at the concentration of 80 μM. Western Blot Analysis[1] Cell Line: PC12 cells Concentration: 10, 20, 40 μM Incubation Time: 30 hours Result: Attenuated p75NTR- and NRAGE-induced c-Jun phosphorylation and caspase-3 cleavage, and the levels of c-Jun protein. |
| References | [1]. Salehi AH, et, al. AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem Biol. 2006 Feb;13(2):213-23. |
Chemical & Physical Properties
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Molecular Formula | C10H8N4O2S2 |
| Molecular Weight | 280.326 |
| Exact Mass | 280.008881 |
| PSA | 126.97000 |
| LogP | 1.32 |
| Index of Refraction | 1.835 |
| InChIKey | MQUYTXDAVCOCMX-UHFFFAOYSA-N |
| SMILES | NS(=O)(=O)c1nn2cc(-c3ccccc3)nc2s1 |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| RIDADR | NONH for all modes of transport |
Articles2
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Synonyms
| hms1538b12 |
| 6-Phenylimidazo[2,1-b][1,3,4]thiadiazole-2-sulfonamide |
| Imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide, 6-phenyl- |
| unii-7ezf1a283n |
