CAS 71800-36-7|Lys- [Des-Arg9] Bradykinin
| Common Name | Lys- [Des-Arg9] Bradykinin | ||
|---|---|---|---|
| CAS Number | 71800-36-7 | Molecular Weight | 1032.20 |
| Density | 1.45g/cm3 | Boiling Point | / |
| Molecular Formula | C50H73N13O11 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | Lys-[Des-Arg9]Bradykinin |
|---|---|
| Synonym | More Synonyms |
Lys- [Des-Arg9] Bradykinin BiologicalActivity
| Description | Lys-[Des-Arg9]Bradykinin, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a Ki of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin has low inhibitory activity on B2 receptors[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic DiseaseSignaling Pathways >>GPCR/G Protein >>Bradykinin Receptor |
| In Vitro | Lys-[Des-Arg9]Bradykinin 由缓激肽的蛋白水解裂解形成，通过缓激肽 B1 受体 (B1R) 发挥作用[1]。 Lys-[Des-Arg9]Bradykinin (Lda-BK; 10 μM) 增强 IL-12p70 的分泌并抑制成熟 hMo-DC 的 IL-12p40 分泌。用 Lys-[Des-Arg9]Bradykinin 预处理可减少成熟 hMo-DC 单独向培养基的迁移，表明 Lys-[Des-Arg9]Bradykinin 可抑制成熟 hMo-DC 的趋化作用[1]。 |
| In Vivo | Lys-[Des-Arg9]Bradykinin (1 μg；鼻腔注射；新西兰大白兔) 处理可降低脂多糖诱导家兔外周血管阻力，但效果短暂(T1/2=118-195 s)[3]。 |
| References | [1]. Rosalind Gulliver, et al. Lys-des[Arg9]-bradykinin alters migration and production of interleukin-12 in monocyte-derived dendritic cells. Am J Respir Cell Mol Biol. 2011 Sep;45(3):542-9. [2]. L M Fredrik Leeb-Lundberg, et al. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev. 2005 Mar;57(1):27-77. [3]. G Drapeau, et al. Hypotensive effects of Lys-des-Arg9-bradykinin and metabolically protected agonists of B1 receptors for kinins. J Pharmacol Exp Ther. 1991 Dec;259(3):997-1003. |
Chemical & Physical Properties
| Density | 1.45g/cm3 |
|---|---|
| Molecular Formula | C50H73N13O11 |
| Molecular Weight | 1032.20 |
| Exact Mass | 1031.56000 |
| PSA | 377.90000 |
| LogP | 1.65640 |
| Index of Refraction | 1.678 |
| InChIKey | AILVBOHFGXNHCC-TZPCGENMSA-N |
| SMILES | NCCCCC(N)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)N1CCCC1C(=O)NCC(=O)NC(Cc1ccccc1)C(=O)NC(CO)C(=O)N1CCCC1C(=O)NC(Cc1ccccc1)C(=O)O |
| Storage condition | −20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles28
More Articles| Potentiation of des-Arg9-kallidin-induced vasoconstrictor responses by metallopeptidase inhibition in isolated human umbilical artery. J. Pharmacol. Exp. Ther. 313(3) , 1355-60, (2005) Several metallopeptidases have been reported to be involved in bradykinin (BK) B(1) receptor agonist metabolism. Our goal was to evaluate in vitro roles of metallopeptidases [e.g., neutral endopeptida... | |
| Kinins and neuroinflammation: dual effect on prostaglandin synthesis. Eur. J. Pharmacol. 546(1-3) , 197-200, (2006) The role of kinins, well known as peripheral inflammatory mediators, in the modulation of brain inflammation is unclear. The present data show that bradykinin, a bradykinin B(2) receptor agonist, enha... | |
| Essential role of TM V and VI for binding the C-terminal sequences of Des-Arg-kinins. Int. Immunopharmacol. 8(2) , 282-8, (2008) In the kallikrein-kinin and renin-angiotensin systems the main receptors, B1 and B2 (kinin receptors) and AT1 and AT2 (angiotensin receptors) respectively, are seven-transmembrane domain G-protein-cou... |
Synonyms
| lysyl-des-arg9-bradykinin |
| h-lys-arg-pro-pro-gly-phe-ser-pro-phe-oh |
| lys-arg-pro-pro-gly-phe-ser-pro-phe |
| MFCD00079826 |
| Lys-[Des-Arg9]-Bradykinin |
