Introduction：Basic information about CAS 76135-31-4|8-Hydroxy-DPAT hydrobromide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 8-Hydroxy-DPAT hydrobromide |
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| CAS Number | 76135-31-4 | Molecular Weight | 328.28800 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C16H26BrNO | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 8-Hydroxy-DPAT hydrobromide,(±)-7-Hydroxy-2-dipropylaminotetralinhydrobromide |
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| Synonym | More Synonyms |
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8-Hydroxy-DPAT hydrobromide BiologicalActivity
| Description | 8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-Hydroxy-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site[1]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
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| Target | 5-HT1A Receptor:8.19 (pIC50) |
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| In Vitro | 8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) has no effect on 5-HT1B binding at concentrations lower than 100 nM[1]. |
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| In Vivo | 8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide; 32, 56, 80, 100 mg/kg; intramuscularly; 15 min prior to the testing session) of the highest dose significantly interferes with sustained attention and reinforcer efficacy (progressive ratio; PR) performance in the 3,4-methylenedioxymethamphetamine (MDMA)-exposed but not control animals[1]. |
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| References | [1]. D N Middlemiss, et al. 8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site. Eur J Pharmacol. 1983 May 20;90(1):151-3. [2]. Michael A Taffe, et al. Cognitive performance of MDMA-treated rhesus monkeys: sensitivity to serotonergic challenge. Neuropsychopharmacology. 2002 Dec;27(6):993-1005. |
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Chemical & Physical Properties
| Molecular Formula | C16H26BrNO |
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| Molecular Weight | 328.28800 |
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| Exact Mass | 327.12000 |
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| PSA | 23.47000 |
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| LogP | 4.32960 |
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| InChIKey | BATPBOZTBNNDLN-UHFFFAOYSA-N |
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| SMILES | Br.CCCN(CCC)C1CCc2cccc(O)c2C1 |
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| Storage condition | 2-8°C |
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Safety Information
Customs
| HS Code | 2922299090 |
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| Summary | 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| 8-OH-DPAT HRr |
| rac-8-Hydroxy-2-dipropylaMinotetralin HydrobroMide |
| Serotonin agonist DPAT |
| 8-OH-DPAT hydrobromide |
| 8-hydroxydipropyl-aminotetralin |
| 8-OH-DPAT HBr |
