Introduction：Basic information about CAS 77307-50-7|SL 0101-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | SL 0101-1 |
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| CAS Number | 77307-50-7 | Molecular Weight | 516.451 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 753.0±60.0 °C at 760 mmHg |
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| Molecular Formula | C25H24O12 | Melting Point | 128-132ºC |
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| MSDS | / | Flash Point | 255.6±26.4 °C |
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Names
| Name | Kaempferol-3-O-(3,4-di-O-acetyl-alpha-L-rhamnopyranoside) |
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| Synonym | More Synonyms |
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SL 0101-1 BiologicalActivity
| Description | SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM. Shows proliferation inhibition in human breast cancer cell line MCF-7 and produces a cell cycle block in G1 phase[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>MAPK/ERK Pathway >>Ribosomal S6 Kinase (RSK) |
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| Target | IC50: 89 nM (RSK)[1]. |
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| References | [1]. Smith JA, et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 2005 Feb 1;65(3):1027-34. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 753.0±60.0 °C at 760 mmHg |
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| Melting Point | 128-132ºC |
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| Molecular Formula | C25H24O12 |
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| Molecular Weight | 516.451 |
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| Flash Point | 255.6±26.4 °C |
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| Exact Mass | 516.126770 |
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| PSA | 182.19000 |
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| LogP | 2.75 |
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| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
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| Index of Refraction | 1.666 |
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| InChIKey | SXOZSDJHGMAEGZ-IGKKHSBFSA-N |
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| SMILES | CC(=O)OC1C(C)OC(Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)C(O)C1OC(C)=O |
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| Storage condition | -20℃ |
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Synonyms
| 4H-1-Benzopyran-4-one, 3-[(3,4-di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)- |
| 3',4'-Di-O-acetylafzelin |
| 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 3,4-di-O-acetyl-6-deoxy-α-L-mannopyranoside |
| 3",4"-Diacetylafezelin |
| SL 0101-1 |
| SL0101 |
