CAS 93839-89-5|Adenosine 5'-[γ-thio]triphosphate Tetralithium Salt
| Common Name | Adenosine 5'-[γ-thio]triphosphate Tetralithium Salt | ||
|---|---|---|---|
| CAS Number | 93839-89-5 | Molecular Weight | 546.979 |
| Density | / | Boiling Point | 940.5ºC at 760 mmHg |
| Molecular Formula | C10H12Li4N5O12P3S | Melting Point | / |
| MSDS | USA | Flash Point | 522.6ºC |
Names
| Name | ATPγS tetralithium salt,Adenosine-5'-(γ-thio)-triphosphatetetralithiumsalt |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | ATPγS (tetralithium salt) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>Eukaryotic Initiation Factor (eIF)Research Areas >>Inflammation/Immunology |
| In Vitro | ATPγS (tetralithium salt) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase[1]. ATPγS (50-100 μM final blood concentration) attenuates inflammatory response with decreased accumulation of cells (48%, P < 0.01) and proteins (57%, P < 0.01) in bronchoalveolar lavage and reduces neutrophil infiltration and extravasation of Evans blue albumin dye into lung tissue[3]. |
| In Vivo | ATPγS (tetralithium salt, 50 μM final, intravenous) demonstrates preserved lung parenchymal architecture[3]. ATPγS results in a dose-dependent effect on EBA extravasation in LPS-treated mice[3]. |
| References | [1]. Matthew L Peck, et al. Adenosine 5'-O-(3-thio)triphosphate (ATPgammaS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. RNA. 2003 Oct;9(10):1180-7. [2]. Z Y Wang, et al. Mg2+ and ATP or adenosine 5'-[gamma-thio]-triphosphate (ATP gamma S) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase. Biochim Biophys Acta. 1993 Sep 3;1202(1):47-55. [3]. Irina A Kolosova, et al. Protective effect of purinergic agonist ATPgammaS against acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L319-24. |
Chemical & Physical Properties
| Boiling Point | 940.5ºC at 760 mmHg |
|---|---|
| Molecular Formula | C10H12Li4N5O12P3S |
| Molecular Weight | 546.979 |
| Flash Point | 522.6ºC |
| Exact Mass | 547.005615 |
| PSA | 334.90000 |
| LogP | 1.47200 |
| InChIKey | DWQFDOIBOYDYKH-KWIZKVQNSA-J |
| SMILES | Nc1ncnc2c1ncn2C1OC(COP(=O)([O-])OP(=O)([O-])OP([O-])([O-])=S)C(O)C1O.[Li+].[Li+].[Li+].[Li+] |
Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
Articles9
More Articles| Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. J. Mol. Biol. 426(15) , 2886-99, (2014) The p97 AAA (ATPase associated with diverse cellular activities), also called VCP (valosin-containing protein), is an important therapeutic target for cancer and neurodegenerative diseases. p97 forms ... | |
| The enzymatic synthesis of thiophosphate analogs of nucleotides. Biochim. Biophys. Acta 276 , 155, (1972) | |
| ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle. Cell 144 , 526-538, (2011) In the eukaryotic 26S proteasome, the 20S particle is regulated by six AAA ATPase subunits and, in archaea, by a homologous ring complex, PAN. To clarify the role of ATP in proteolysis, we studied how... |
Synonyms
| Tetralithium 5'-O-[({[(dioxidophosphorothioyl)oxy]phosphinato}oxy)phosphinato]adenosine |
| Adenosine, 5'-O-[hydroxy[[hydroxy[(hydroxymercaptophosphinyl)oxy]phosphinyl]oxy]phosphinyl]-, lithium salt (1:4) |
